This thesis's purpose is to present a comprehensive overview of amyotrophic lateral sclerosis (ALS), thus providing the reader with the needed knowledge to understand the roots behind the limitations encountered in treating the disease.

The thesis delves into ALS epidemiology, pathology, and clinical aspects before concluding with the current trends in pharmacotherapy. It discusses their pharmacodynamics and pharmacokinetics, in addition to their authorisation status and hurdles encountered in the clinical trial phases.