Adenosine receptor agonist play role in treatment of cardiovascular disease. It can regulate the pacemaker activity, atrioventricular conduction, myocardial contractility, it also can reduce the heart rate therefore it can be use in various forms of arrhythmia such as supra ventricular tachycardia, but it may cause bradycardia as a side effects. These agonists can result in better coronary circulation by moderate vasodilation of coronary vessels.