Determination of effects of Raf-1 on the regulation of MLC phosphorylation in the primary human intestinal smooth cell

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dc.contributor.advisorUray, Karen
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Orvosi Vegytani Intézethu_HU
dc.contributor.authorKola, Job Baffin
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentSzatmári, István
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Biokémiai és Molekuláris Biológiai Intézethu_HU
dc.date.accessioned2019-06-27T05:37:16Z
dc.date.available2019-06-27T05:37:16Z
dc.date.created2019-06-26
dc.description.abstractPostoperative ileus arises when normal propulsion of food in the small intestine, is obstructed due to problems with smooth muscle contractility or enteric nervous system pathologies. Close to 26% of trauma patients were diagnosed with ileus (Virani et al 2018) Abdominal surgeries (50%) (Yin et al 2015). POI delays enteral feeding which increases the length of hospital stays (Vather, O'Grady, Bissett, & Dining, 2014). Inflammation is a major contributor to postoperative ileus. Currently, there is no single efficient strategy to reduce postoperative ileus significantly. This study focuses on the effects of CXCL1, a cytokine upregulated in smooth muscle after the induction of ileus.hu_HU
dc.description.correctorLB
dc.description.coursemolekuláris biológiahu_HU
dc.description.courselangangolhu_HU
dc.description.coursespecBiokémia-genomikahu_HU
dc.description.degreeMSc/MAhu_HU
dc.format.extent32hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/270011
dc.language.isoenhu_HU
dc.subjectPOI (Post-operative ileus)hu_HU
dc.subjectCXCL1/CXCR2 signaling
dc.subjectMLC (myosin light chain)
dc.subjectMYPT1 (myosin light chain phosphatase targeting subunit 1)
dc.subjectPAK (p21 activated kinase)
dc.subjectROCK (Rho-kinase)
dc.subjectMLCP (myosin light chain phosphatase)
dc.subjectMLCK (myosin light chain kinase)
dc.subjectIL8 (interleukin 8)
dc.subjectNSAID (Nonsteroidal anti-inflammatory drugs)
dc.subject.dspaceDEENK Témalista::Biológiai tudományok::Sejtélettanhu_HU
dc.titleDetermination of effects of Raf-1 on the regulation of MLC phosphorylation in the primary human intestinal smooth cellhu_HU
dc.title.translatedA Raf-1 hatásainak meghatározása az MLC foszforiláció szabályozására az elsődlegesben emberi bél sima sejt.hu_HU
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Theses (Faculty of Medicine)