Pesticide plays an important role in agriculture and public health. Improper use of pesticide can cause harm to the environment and human health. This research provides information on pesticide use in developed and developing countries. Comparing Vietnam and Hungary, we can see the difference in pesticide use and the trend over 28-year period. The increase in pesticide use is directly proportional to risk of affecting human health. To improve quality of life, it’s a must to reduce pesticide use and have alternative solution.