Studies on the Effect of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein on Macrophage Polarization

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dc.contributor.advisorMahdi, Mohamed
dc.contributor.advisorAl-Muffti, Aya
dc.contributor.authorAbu-leil, Sofia
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Biológiai és Ökológiai Intézet
dc.date.accessioned2025-06-19T07:08:48Z
dc.date.available2025-06-19T07:08:48Z
dc.date.created2025-05-06
dc.description.abstractThis thesis investigates the impact of the SARS-CoV-2 spike (S) protein on macrophage polarization and cytokine secretion. The spike protein, central to viral entry and the primary antigen in most COVID-19 vaccines, was studied using transfection of THP-1-derived macrophages. Our findings showed that spike expression did not significantly shift macrophages toward either M1 or M2 phenotypes. However, a modest but statistically significant increase in IFN-α secretion was observed in M2-polarized cells. No such increase was seen in M1 macrophages. These findings contribute to a broader understanding of how spike protein may subtly influence immune responses, with implications for viral pathogenesis and vaccine design.
dc.description.courseBiology
dc.description.degreeBSc/BA
dc.format.extent26
dc.identifier.urihttps://hdl.handle.net/2437/393403
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectSARS-CoV-2
dc.subjectCoronavirus
dc.subjectMacrophage
dc.subjectPolarization
dc.subjectSpike
dc.subject.dspaceBiology
dc.titleStudies on the Effect of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein on Macrophage Polarization
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