Synthesis of glycopyranosylidene-spiro-isoxazolines

A tétel rövid nézete
dc.contributor.advisorVágvölgyiné Tóth, Marietta
dc.contributor.authorShafique, Hina
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Kémiai Intézet
dc.date.accessioned2023-05-08T07:07:33Z
dc.date.available2023-05-08T07:07:33Z
dc.date.created2023
dc.description.abstractResearchers at the University of Debrecen's Chemical Glycobiology Research Group are investigating the reactivity of anhydro-aldose-oximes derived nitrile oxides. The goal of the thesis is to examine 1,3-dipolar cycloaddition reactions of these nitrile oxides with exo-glycals. This is to form new glycopyranosylidene-spiro-isoxazoline derivatives as potential glycomimetics. The team synthesized 3,4,5,7-Tetra-O-benzoyl-2,6-anhydro-D-glycero-D-gulo-heptose-oxime(52) from 2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl-cyanide(46) in two steps. They also synthesized exo-glycals in two steps. The researchers carried out optimization reactions and cycloaddition reactions of oxime 52 with exo-glucal 48 and exo-glactal 50. They successfully obtained glucopyranosylidene-spiro-isoxazoline derivatives in good yields
dc.description.correctorLB
dc.description.courseChemistry
dc.description.degreeBSc/BA
dc.format.extent31
dc.identifier.urihttps://hdl.handle.net/2437/352135
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectSynthesis
dc.subjectOrganic Synthisis
dc.subject.dspaceDEENK Témalista::Kémia
dc.titleSynthesis of glycopyranosylidene-spiro-isoxazolines
dc.title.subtitleSynthesis
Fájlok
Gyűjtemények
Theses (Faculty of Science and Technology)