Role of p53 and PARP-1 in neurodegenerative diseases

Abstract

The thesis presents a general review of major neurodegenerative diseases and also discusses the role of p53 and PARP-1 in neurodegeneration. p53 and PARP-1 are 2 very essential proteins involved in cell-cycle regulation, cell death, DNA repair etc. Their role should be elucidated further to understand the pathomechanism but also protection against neurodegeneration.