Molecular background of Kv 1.3 channels recovery from C-type inactivation

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dc.contributor.advisorHajdu, Péter Béla
dc.contributor.advisorNagy, Sándor
dc.contributor.authorNguyen, Xuan Tung
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Fizikai Intézethu_HU
dc.date.accessioned2020-05-14T09:28:19Z
dc.date.available2020-05-14T09:28:19Z
dc.date.created2020-05-12
dc.description.abstractThis thesis determines how the recovery from inactivation is regulated by the molecular mechanism attributed to the various functional entities of the channels and what the role of individual subunits in this process. To answer this question, we determined the membrane potential dependence of recovery parameters in wide-type and mutant homotetrameric channels, and evaluated the recovery of heteromeric channels (containing mutant and wild-type subunits). The results showed that during the recovery from inactivation cooperativity exists between the subunits. Therefore, the result predicts the dominating role of mutant subunits in the time-course of transition from inactivated to closed/recovered state.hu_HU
dc.description.correctorhbk
dc.description.coursePhysicshu_HU
dc.description.degreeBSc/BAhu_HU
dc.format.extent22hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/287193
dc.language.isoenhu_HU
dc.subjectBiophysicshu_HU
dc.subjectRecovery from inactivation of Kv 1.3 channelshu_HU
dc.subject.dspaceDEENK Témalista::Fizikahu_HU
dc.titleMolecular background of Kv 1.3 channels recovery from C-type inactivationhu_HU
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