The human P-glycoprotein (ABCB1) and its role in the multidrug resistance of cancers

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dc.contributor.advisorGoda, Katalin
dc.contributor.authorAmankossova, Nazerke
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Biológiai és Ökológiai Intézethu_HU
dc.date.accessioned2022-05-10T07:03:46Z
dc.date.available2022-05-10T07:03:46Z
dc.date.created2022-05-06
dc.description.abstractMultidrug resistance is a significant impediment to the successful treatment of neoplastic disorders. This type of treatment resistance has been studied in both cultivated tumor cell lines and clinical tumors. ABCB1 appears to play a critical role in these cells by serving as an energy-dependent efflux pump, removing numerous natural product medicines from the cell prior to their cytotoxic effects being exerted. ABCB1 (P-gp, MDR1) is an ABC transporter protein that is produced by the MDR1 gene. ABCB1 activity can significantly affect the pharmacokinetics of numerous chemotherapeutic drugs and thus the effectiveness of chemotherapy treatments of various diseases. On the other hand, simultaneous use of ABCB1 inhibitor drugs and ABCB1 substrate drugs may increase the blood concentration and intracellular concentration of the latter, which may increase the risk of unwanted drug-drug interactions and side-effects.hu_HU
dc.description.courseBiologyhu_HU
dc.description.degreeBSc/BAhu_HU
dc.format.extent26hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/332900
dc.language.isoenhu_HU
dc.subjectCancer cellshu_HU
dc.subjectP-gphu_HU
dc.subjectABCB1hu_HU
dc.subjectmultidtug resistancehu_HU
dc.subject.dspaceDEENK Témalista::Biológiai tudományokhu_HU
dc.titleThe human P-glycoprotein (ABCB1) and its role in the multidrug resistance of cancershu_HU
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