dc.contributor.advisor	Panyi, György
dc.contributor.author	Cozzolino, Marco
dc.contributor.department	Molekuláris orvostudomány doktori iskola	hu
dc.contributor.submitterdep	Általános Orvostudományi Kar::Biofizikai és Sejtbiológiai Intézet
dc.date.accessioned	2024-10-09T10:02:02Z
dc.date.available	2024-10-09T10:02:02Z
dc.date.defended	2024-10-24
dc.date.issued	2024
dc.description.abstract	My dissertation focuses on the effect of pH variations on the activity of two ion channels. In the first part, I demonstrate the presence of the pH-sensitive proton channel Hv1 in MDSC (myeloid-derived suppressor cells) using various biophysical, pharmacological, and imaging methods. In the second part, I investigate the effect of pH variations on KCa3.1 and its activators Riluzole and SKA-31, showing tha KCa3.1 is not immediately affected by pH, but its modulators are. In particular, I demonstrated that the intracellular acidification will impair the functionality of Riluzole and SKA-31.
dc.format.extent	93
dc.identifier.uri	https://hdl.handle.net/2437/380914
dc.language.iso	en
dc.subject	kca3.1
dc.subject	hv1
dc.subject	immunology
dc.subject	ion channels
dc.subject	patch clamp
dc.subject.discipline	Elméleti orvostudományok	hu
dc.subject.sciencefield	Orvostudományok	hu
dc.title	pH and pH gradients regulate the Hv1 ion channel in myeloid-derived suppressor cells and modulate the pharmacology of the KCa3.1 channel of T cells
dc.title.translated	pH and pH gradients regulate the Hv1 ion channel in myeloid-derived suppressor cells and modulate the pharmacology of the KCa3.1 channel of T cells
dc.type	PhD, doktori értekezés	hu

pH and pH gradients regulate the Hv1 ion channel in myeloid-derived suppressor cells and modulate the pharmacology of the KCa3.1 channel of T cells

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