15-membered rigid macrocyclic ligand for Mn2+ complexation: synthesis and coordination chemical characterization

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dc.contributor.advisorTircsó, Gyula
dc.contributor.authorBaghirova, Aghanana
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Kémiai Intézet
dc.date.accessioned2024-12-20T08:48:24Z
dc.date.available2024-12-20T08:48:24Z
dc.date.created2024-11-22
dc.description.abstractThe investigation of Mn²⁺ chelates as alternatives to Gd³⁺-based MRI contrast agents has gained significant attention due to their promising safety and performance profiles. My research focused on the synthesis and coordination chemistry of a novel 15-membered bipyridine-based macrocyclic ligand, 15-BPyN5. The ligand demonstrated excellent thermodynamic stability (log K_MnL = 13.44), high kinetic inertness, and favorable relaxivity properties (r1p/r2p = 3.60/6.60 mM⁻¹s⁻¹). Dissociation studies revealed slow exchange kinetics with Zn²⁺ ions, with half-lives of 79.0 and 28.7 hours at 25°C and 37°C, respectively, attributed to the rigid coordination environment provided by the bipyridine moiety. These properties highlight the potential of [Mn(15-BPyN5)] as a safe and effective MRI contrast agent. This work paves the way for developing non-toxic alternatives to gadolinium-based agents, offering improved safety and imaging performance.
dc.description.courseChemistry
dc.description.degreeBSc/BA
dc.format.extent36
dc.identifier.urihttps://hdl.handle.net/2437/384084
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectMacrocyclic ligands
dc.subjectMn²⁺ complexation
dc.subjectCoordination chemistry
dc.subject.dspaceKémia::Fizikai kémia
dc.title15-membered rigid macrocyclic ligand for Mn2+ complexation: synthesis and coordination chemical characterization
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