Formulation and Evaluation of Sodium Alginate-Based Hydrogels

Abstract

This thesis explores the formulation and evaluation of sodium alginate-based hydrogels as potential wound healing agents. Hydrogels were prepared using sodium alginate crosslinked with calcium chloride and enhanced with nicotinamide, known for its anti-inflammatory and regenerative properties. Key parameters such as pH, texture, drug diffusion, and cytotoxicity were analyzed to assess their suitability for topical application. Results showed that increasing sodium alginate concentration improved gel strength and initial drug release, while maintaining pH within the skin-compatible range. The MTT assay confirmed good biocompatibility at lower alginate concentrations. These findings support the potential of alginate-based hydrogels in modern wound care.