Theses (Faculty of Pharmacy)
Állandó link (URI) ehhez a gyűjteményhez
Theses collection of the Faculty of Pharmacy. The collection was started in 2015.
At the University of Debrecen, in accordance with the 2022 amendment to the 2011 Higher Education Act, student theses are only accessible from devices connected to the University's Eduroam WiFi network or from a university IP address.
“The thesis or diploma work of a student who has successfully passed the final examination shall be stored in full in the academic system of the higher education institution, and a record shall be maintained thereof. The stored theses and diploma works – with the exception of parts classified as confidential in accordance with the relevant legislation – must be made accessible and searchable without restriction through the academic system.” Further info on the National Higher Education Act in Hungarian: Felsőokt. tv. (új) - 2011. évi CCIV. törvény a nemzeti felsőoktatásról - Hatályos Jogszabályok Gyűjteménye.
Böngészés
legfrissebb feltöltések
Megjelenítve 1 - 20 (Összesen 201)
Tétel Korlátozottan hozzáférhető Biological studies of heterobimetallic complexes as hypoxia-activated anticancer prodrugsEigbe, Ehiremhen Yvonne; Sipos, Éva; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Haimhoffer, Adam; Varga, Balázs; Gyógyszerésztudományi Kar; Általános Orvostudományi KarCancer remains a major cause of death worldwide, and while Pt(II) drugs like cisplatin are effective, their lack of selectivity leads to significant side effects. To address this, researchers are exploring alternative metal complexes with better targeting, such as Co(III) compounds that act as hypoxia-activated prodrugs. These complexes remain inactive in normal oxygen conditions but become activated in the low-oxygen environment of tumors, releasing a cytotoxic ligand derived from the iron chelator Deferiprone. In this study, newly synthesized Co(III)-based complexes and the ligand were tested on MCF-7 breast cancer cells under both normoxic and hypoxic conditions using cytotoxicity assays and RT-qPCR. Results showed that the Co(III) complex exhibited selective activation under hypoxia, with reduced toxicity in normal conditions, while the ligand induced gene expression consistent with iron chelation. Overall, the findings suggest that Co(III) complexes could serve as targeted carriers for anticancer agents, and iron chelators may also have therapeutic potential.Tétel Korlátozottan hozzáférhető Biological studies of iron chelating agent KN1 and cobalt containing complex KNK 0.1 as hypoxia-activated anticancer prodrugsPhan Trung, Phuong; Sipos, Éva; Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; DE--Gyógyszerésztudományi Kar; Pető, Ágota; Homolya, Ágnes; Gyógyszerésztudományi Kar; Gyógyszerésztudományi Kar::Gyógyszerészi Kémiai TanszékThis research explores (PGM, Co(III)) heterobimetallic complexes as a targeted alternative to traditional Pt(II) therapies like cisplatin, which are often limited by systemic toxicity and drug resistance. The study specifically evaluates KN1 (DTBC), an iron-chelating ligand, and KNK 0.1 (Co(tren)DTBC), a cobalt-based prodrug designed for selective activation. Using two-way ANOVA for data analysis, the drugs were tested against the MCF-7 breast cancer cell line across 24-hour and 72-hour intervals under both normoxic and hypoxic conditions. Results indicated that while KN1 exhibits moderate cytotoxicity, KNK 0.1 effectively functions as a hypoxia-activated anticancer prodrug, releasing its cytotoxic payload specifically in oxygen-deficient environments. Ultimately, this work demonstrates the potential of cobalt-containing complexes to improve tumor selectivity and reduce the side effects typically associated with conventional chemotherapy.Tétel Korlátozottan hozzáférhető Marfan-szindróma ismertetése és kezelése MagyarországonPáll, Virág Anna; Fésüs, Adina; Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; DE--Gyógyszerésztudományi Kar; Lekli , István; Dobos, Nikoletta; Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; Gyógyszerésztudományi Kar::Biofarmácia TanszékA Marfan-szindróma ritka, autoszomális domináns öröklődésű kötőszöveti betegség, amelyet leggyakrabban az FBN1 gén mutációja okoz. Elsősorban a kardiovaszkuláris rendszert, a vázrendszert és a szemet érinti, tünetei pedig egyénenként nagyon változatosak lehetnek. Legsúlyosabb szövődménye az aortagyök tágulata és az ebből kialakuló aortadisszekció. A diagnózis alapját a Ghent-2 kritériumrendszer, a klinikai jelek, a képalkotó vizsgálatok és a genetikai tesztek adják. A kezelés célja az aortatágulat progressziójának lassítása, amelyben főként béta-blokkolók és angiotenzinreceptor-blokkolók alkalmazhatók, szükség esetén műtéttel kiegészítve. A betegek életkilátásai jelentősen javíthatók korai felismeréssel, rendszeres ellenőrzéssel és komplex, több szakterületet érintő gondozással.Tétel Korlátozottan hozzáférhető Microneedle-Assisted Transdermal Drug delivery systems: material, design and skin interactionShojaei, Yalda; Peto, Agota; DE--Gyógyszerésztudományi KarMicroneedle transdermal patches are explored as a promising alternative to traditional drug delivery methods. The structure of the skin and the limitations of conventional transdermal patches and injections have been reviewed to highlight the need for new approaches. The design, materials, drug-loading strategies, and release mechanisms of microneedles are discussed to explain how they can effectively deliver drugs through the skin while remaining comfortable for patients. Depending on their design, these systems can provide immediate, sustained, or stimulus-responsive drug release. Microneedles also have a wide range of applications, including vaccination, diabetes management, hormone delivery, cancer therapy, and cosmetic treatments, with increasing interest in personalized medicine. Overall, they represent a promising step forward in drug delivery, although further research is still needed for wider clinical and commercial use.Tétel Korlátozottan hozzáférhető Formulation and evaluation of a tipical preparation containing RoflumilastMahdavi, Mahyar; Pető, Ágota; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; DE--Gyógyszerésztudományi Kar; Bácskay, Ildikó; Bak, Istvan; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; Gyógyszerésztudományi Kar::Gyógyszerhatástani TanszékPsoriasis is a chronic, proliferative, inflammatory dermatologic disease that accelerates the skin cell proliferation rate from 26-28 days to 3-4 days, resulting in increased skin thickness and cutaneous plaques. Its symptoms are red lesions with white scales and silver colored flakes, accompanied by a burning sensation and pruritus. The most common type of psoriasis is Plaque Psoriasis; topical agents are also the best therapeutic approach in the case of Mild-to-Moderate Plaque Psoriasis. Roflumilast is a selective phosphodiesterase-4 (PDE-4) inhibitor that was approved as a topical agent in the case of mild-to-moderate plaque psoriasis by the U.S. Food and Drug Administration (FDA). Its mechanism of action in this skin disease is not yet fully understood, but it likely provides anti-inflammatory effects. This paper aimed to formulate and evaluate a nanogel containing Roflumilast. Two gel compositions were prepared with and without hydroxypropyl-beta-cyclodextrin (HPBCD). Physicochemical characterization included pH measurement, rheological analysis, particle size analysis, and in vitro drug-release studies. Both nanogels showed acceptable values in the case of pH measurements. Rheology analysis confirmed shear-thinning behavior, which is favorable for topical preparations. Particle size analysis demonstrated smaller values for the nanogel containing Roflumilast and HPBCD compared to the nanogel containing Roflumilast. An in-vitro drug release study indicated higher drug release in the case of the nanogel containing Roflumilast and HPBCD. In conclusion, Roflumilast nanogels were successfully formulated and showed suitable physicochemical properties for topical use. The incorporation of HPBCD increased the solubility of Roflumilast in Tween 80, reduced particle size, and enhanced drug release.Tétel Korlátozottan hozzáférhető The relationship between alcohol consumption and antidepressant use in some European countriesAhmed , Mohamed; László, Horváth; Gyógyszerésztudományi Kar::Gyógyszerfelügyelet és Gyógyszergazdálkodási Tanszék; DE--Gyógyszerésztudományi Kar; Váradi, Judit; Fenyvesi, Ferenc; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; Gyógyszerésztudományi Kar::Gyógyszertechnológiai TanszékAlcohol consumption and depression have become one of the great public health challenges facing the world and they are directly related to biological, psychological and social means. Antidepressants are one of the most frequently administered classes of drugs to treat depressive disorders, and particularly in high income European countries.Tétel Korlátozottan hozzáférhető Evaluation Of The Antiproliferative Effects Of Newly Synthesized Cyclodextrin DerivativesMai, Fatima Aminu; Ferenc, Fenyvesi; DE--Gyógyszerésztudományi KarThe thesis focuses on the application of cyclodextrin in enhancing the effect of Fluorouracil on HCT116 and Caco-2 cell lines. The study was designed to evaluate the potential effectiveness and interactions of these compounds in a controlled in vitro environment. The methodology used was appropriate for the research objectives and allowed for reliable and reproducible results. The findings contribute to a better understanding of how cyclodextrin can improve drug delivery. Some limitations were encountered but they did not affect the overall outcome of the study. Overall this work demonstrates the relevance of the topic and provides a foundation for further research in anticancer drug development.Tétel Korlátozottan hozzáférhető Biocompatibility and bioavailability studies of a vaginal gel containing hydroxypropyl-beta-cyclodextrin complexesTorabi Mousavi, Seyedhadi; Fenyvesi, Ferenc; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Horváth, László; Arany, Petra; Gyógyszerésztudományi KarVaginal gels are widely used for the treatment of local vaginal infections, contraception, and the symptoms of menopause. Hormone replacement therapy can be an efficient method for the treatment of menopausal symptoms, and the local application of low-dose estrogen hormones in the vagina improves the safety of the therapy. Our aim is to test an estrogen hormone-containing vaginal gel, which contains estrogens in a hydroxypropyl-betacyclodextrin (HPβCD) complex. Estrogens are insoluble in water; however, their complexation with HPβCD improves its water solubility and bioavailability in the vaginal environment. HPβCD is a widely used cyclic oligosaccharide, improves the solubility of poorly soluble drugs, considered to be safe and non-toxic but the vaginal application of this excipient has not been studied yet. The work aims at testing the vaginal gel on HaCat keratinocyte cell line and SkinEthicTM HVE / Human Vaginal Epithelium model for biocompatibility and toxicity studies. MTT and LDH tests are used for the determination of the toxicity of the gel and its components on the cell line and the vaginal model. The Human Vaginal Epithelium model is also used for determining the amount of estriol permeated through the epithelial cell layers. The effect of the HPβCD -complex on cell proliferation was examined by a wound-healing assay, which may provide new information about the tissue regenerative effects of the complex. The study helps to obtain new data about the safety and efficacy of the vaginal application of HPβCD and its estrogen complex.Tétel Korlátozottan hozzáférhető Manufacturing of theophylline-containing hydrophilic matrix tablets and the effect of formulation variation and granulation type on the diameter/height ratio.Saadati, Sanaz; Arany , Petra; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; DE--Gyógyszerésztudományi Kar; Gonda , Sándor; Bege , MiklósThis thesis investigates the manufacturing of theophylline-containing hydrophilic matrix tablets, focusing on the effect of formulation and granulation methods on tablet properties. Direct compression was unsuccessful due to poor flowability and compressibility, leading to the use of wet granulation. However, Carbopol® 71G caused excessive stickiness, which was resolved by replacing it with Carbopol® 974P. Since wet granulation did not provide sufficient mechanical strength, hot-melt granulation was applied as an alternative. This method produced denser granules and tablets with improved hardness and stability. Overall, the results demonstrate that granulation technique and formulation composition play a critical role in successful tablet development.Tétel Korlátozottan hozzáférhető Exploring PD-L1 and PD-L2 as Possible Biomarkers in Renal CancerSEYED PIRAN, SEYED BEHRAD; Szabó , Zsuzsanna; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Dobos, Nikoletta; Szabó, Erzsébet; Gyógyszerésztudományi KarThis study explores how two proteins, PD-L1 and PD-L2, may help predict treatment results in people with kidney cancer, specifically renal cell carcinoma (RCC). Researchers compared cancer tissue and nearby healthy kidney tissue from 20 patients and found both proteins were expressed more in tumors. Especially in aggressive tumors (Grade 4), PD-L1 and PD-L2 levels were much higher, suggesting a link between these proteins and tumor severity. One case showed unusually high PD-L1 even in a less aggressive tumor, hinting at differences between individual tumors. The findings suggest that targeting both proteins could improve treatment results, especially for high-risk patients. The study supports the use of these proteins to better match patients with the right immune therapy.Tétel Korlátozottan hozzáférhető Synthetic Derivatives of C. sativa as Potential Drug Candidates Against Cutaneous Melanoma CellsGholami, Soheyla; Szabó , Erzsébet; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Tosaki, Agnes; Szabó, Zsuzsanna; Gyógyszerésztudományi KarThis study looks at two synthetic compounds made from Cannabis sativa, named PFD-11A and PFD-35/II, and how they affect skin cancer cells called melanoma. These cancer cells are usually hard to treat, so new drug options are needed. The researchers tested the compounds on two different melanoma cell lines and found that PFD-35/II was more effective at killing the cells. The drugs reduced the cancer cells’ ability to grow and survive over time. They also seemed to work by triggering processes like autophagy and cell death. The findings suggest these compounds could be useful for treating melanoma, but more research, especially in animals, is needed to confirm this.Tétel Korlátozottan hozzáférhető Development of Ketoprofen Orally Disintegrating Tablets (ODT) for Pediatric UseMohammadian, Kimia; Vasvári, Gábor; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Rusznyák, Ágnes; Nemes, DánielThis thesis presents the development of an orally disintegrating tablet (ODT) formulation containing ketoprofen, intended for pediatric use. The aim was to create a child-friendly dosage form with rapid disintegration, adequate mechanical strength, and acceptable taste. A range of excipients, including co-processed blends of lactose, microcrystalline cellulose (MCC), and low-substituted hydroxypropyl cellulose (L-HPC), were evaluated to optimize the formulation. Comprehensive assessments were conducted on hardness, disintegration time, and dissolution behavior to identify the most effective composition. The findings demonstrate the potential of this formulation approach to enhance pediatric compliance and therapeutic effectiveness. The study contributes to the advancement of innovative drug delivery systems tailored for pediatric patients.Tétel Korlátozottan hozzáférhető Reported cutaneous allergies to antimicrobials in EudraVigilanceChiwara, Tonderai Asher; László , Horváth; Gyógyszerésztudományi Kar::Gyógyszerfelügyelet és Gyógyszergazdálkodási Tanszék; DE--Gyógyszerésztudományi KarThe thesis is a retrospective analysis of cutaneous adverse drug reactions that occurred after taking antibiotics, with a study period that covers a 10-year period from 2013 to 2023. The database used is EudraVigilance, and the API's analysed were from the J01 Category of the ATC code system. Keywords used were obtained from MedDRA to determine which Adverse Events were related to drug hypersensitivity. Microsoft Excel was then used to sort the data and provide it in the form of descriptive statistics. The aim was to provide real-time up to date big data on the adverse drug reactions that occurred, which will help healthcare professionals in decision making when prescribing medication.Tétel Korlátozottan hozzáférhető prevalence and patterns of NSAIDs use among university studentsYaqub Ojali, Faeza; Tóth, Bèla; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Vercsernyés, Miklós Imre; Váradi, Judit; Gyógyszerésztudományi Kar; Gyógyszerésztudományi KarThe thesis explores the prevalence and patterns of NSAIDs use among university students. It highlights how common self-medication is within this population and draws attention to the limited awareness of its potential side effects. The study shows that many students rely on over-the-counter medications without consulting healthcare professionals. Factors influencing their choices include accessibility, perceived safety and lack of knowledge. The findings emphasises the need for targeted educational interventions to promote safer drug use.Tétel Korlátozottan hozzáférhető Formulation of Alginate Nanoparticles from Green Pea ExtractNadri, Ehsan; Bácskay, IIdikó; Sinka, Dávid zsolt; DE--Gyógyszerésztudományi KarThis thesis explores a novel way to harness the health benefits of green pea extract / by improving its stability and bioavailability using sodium alginate-based nanoparticles. Green peas are rich in fiber, antioxidants, and plant-based nutrients with proven benefits for digestion, blood sugar control, heart health, and more. However, their natural compounds are sensitive and degrade easily, limiting their use in medicines or health supplements. To address this, the study developed and tested a nanoparticle encapsulation system using calcium-alginate beads. This method helps protect the green pea extract and enables a controlled, slow release over time—ideal for both pharmaceutical and food applications. Key Findings: • Nanoparticles averaged ~149 nm in size with a stable surface charge (zeta potential: -15.56 mV). • Encapsulation efficiency was high at 92%, meaning most of the extract was successfully enclosed within the beads. • The beads absorbed water well (EWU: ~79%), indicating good swelling behavior. • Dissolution studies showed gradual release, with over 58% of the extract released in one hour. Overall, the research shows that alginate nanoparticles are a promising vehicle for delivering plant-based bioactives like green pea extract in a more effective and stable way.Tétel Korlátozottan hozzáférhető Investigation of fluorinated CBD derivatives protective effects against Doxorubicin cardiotoxicityNgo, Dang Minh Anh; István, Lekli; Kajtár, Richárd; Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; DE--Gyógyszerésztudományi Kar; Király, Jószef; Gyöngyösi, Alexandra; Gyógyszerésztudományi Kar::Biofarmácia Tanszék; Gyógyszerésztudományi Kar::Gyógyszerhatástani TanszékThe thesis aims to investigate the newly synthesized, fluorinated CBD derivatives on their protective effect against cardiotoxicity induced by Doxorubicin, a well-known chemotherapeutic agent. Several tests were carried out, such as antioxidant assays, MTT assay, MitoSOX staining and Western blot analysis. Antioxidant capacity of the derivatives were thoroughly studied, since the elevation of oxidative stress is one of the major mechanisms of Doxorubicin. The results suggested that the flourinated derivatives, especially molecule 17, showed a higher cell viability, better antioxidant effect and thus better cardioprotection, comparing to CBD. However, further research is required to ensure the safety and effect of the compounds.Tétel Korlátozottan hozzáférhető Comparative study of niacinamide cream and gelfamilbakhtiari , helia; Boros-Kósa, Dora; DE--Gyógyszerésztudományi KarThis thesis explores the use of niacinamide, a form of vitamin B3, in skincare. Niacinamide is known for its benefits in improving skin texture, reducing inflammation, and supporting the skin barrier. Two different topical products containing niacinamide cream and gel were prepared and compared. The goal was to see how each one affects the skin and how well niacinamide can be absorbed. Both products were found to be safe and effective, but the gel allowed better delivery of niacinamide into the skin. These results support the use of niacinamide in modern cosmetic and dermatological formulations.Tétel Korlátozottan hozzáférhető pharmaceutical development of vaccineSamimi, Mana; Ujhelyi, Zoltan; DE--Gyógyszerésztudományi KarThis thesis presents a comprehensive study on the pharmaceutical development of vaccines, focusing on scientific, technical, and regulatory processes. It covers key aspects such as antigen selection, adjuvant formulation, clinical trials, manufacturing, and global distribution. Special emphasis is placed on innovative technologies like mRNA platforms and the challenges of vaccine accessibility and hesitancy. The research aims to highlight both current advancements and future directions in vaccinology, contributing to improved public health strategies worldwide.Tétel Korlátozottan hozzáférhető Treatments of acute heart failureNadri, Mehrnaz; Lekli, István; DE--Gyógyszerésztudományi KarAcute Heart Failure (AHF) is a critical cardiovascular condition that leads to a sudden decline in cardiac function, often requiring urgent medical intervention. Unlike chronic heart failure, AHF develops rapidly and is triggered by underlying conditions such as myocardial infarction, hypertension, arrhythmias, or valvular disease. The high morbidity and mortality associated with AHF highlight the importance of timely diagnosis and effective treatment strategies. AHF arises due to various precipitating factors, including myocardial infarction, hypertension, arrhythmias, valvular disease, pulmonary embolism, sepsis, and non-compliance with medications. Myocardial infarction (heart attack) results in ischemic injury, impairing contractility and reducing cardiac output. Hypertension causes chronic pressure overload, leading to left ventricular hypertrophy and heart failure. Arrhythmias, such as atrial fibrillation, disrupt efficient cardiac output, while valvular diseases, including stenosis and regurgitation, increase cardiac workload. Pulmonary embolism obstructs blood flow to the lungs, straining the right heart, whereas sepsis induces systemic inflammation and myocardial dysfunction. Additionally, non-compliance with heart failure medications can precipitate acute decompensation. The pathophysiology of AHF involves structural and functional changes in the heart. Reduced stroke volume results from weakened myocardial contractility, leading to inadequate cardiac output. Increased filling pressure occurs due to blood accumulation in the heart chambers, causing congestion and pulmonary edema. Elevated afterload, characterized by higher vascular resistance, further impairs the heart’s ability to pump efficiently. These disruptions in the cardiac cycle contribute to the worsening of symptoms and disease progression. The primary goal of AHF treatment is to alleviate symptoms, optimize cardiac function, and prevent deterioration. Pharmacological interventions are the cornerstone of management, with various drug classes playing crucial roles. Diuretics, such as furosemide and bumetanide, reduce fluid overload by increasing urine output, alleviating pulmonary and systemic congestion. However, they may cause hypokalemia, hypotension, and renal dysfunction. Vasodilators, including nitroglycerin and nitroprusside, decrease preload and afterload to improve cardiac efficiency and relieve congestion, but they carry risks of hypotension and reflex tachycardia. Inotropic agents, such as dobutamine, milrinone, and levosimendan, enhance myocardial contractility in severe AHF cases, improving cardiac output. However, they can increase the risk of arrhythmias, hypotension, and myocardial oxygen demand. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) help reduce afterload and prevent cardiac remodeling, improving long-term survival. Despite their benefits, these drugs can cause hyperkalemia, hypotension, and a persistent cough (in the case of ACE inhibitors). Aldosterone antagonists, including spironolactone and eplerenone, counteract fluid retention and cardiac fibrosis, further improving patient outcomes. However, they pose a risk of hyperkalemia and, in the case of spironolactone, gynecomastia. Beta-blockers, such as carvedilol (also α1-blocker), metoprolol, and bisoprolol, reduce sympathetic overactivity, decreasing heart rate and myocardial oxygen demand. These agents prevent cardiac remodeling and reduce hospitalizations but may cause bradycardia, fatigue, and hypotension. Vasopressors, including norepinephrine and dopamine, are essential in cardiogenic shock, maintaining blood pressure and organ perfusion. However, their vasoconstrictive effects can lead to arrhythmias, ischemia, and renal hypoperfusion. Potential drug interactions must be carefully managed in AHF treatment. Loop diuretics combined with NSAIDs can reduce diuretic efficacy and worsen fluid retention. ACE inhibitors or ARBs, when used with potassium-sparing diuretics, significantly increase the risk of hyperkalemia. Beta-blockers combined with calcium channel blockers can cause severe bradycardia, while aldosterone antagonists used alongside NSAIDs can increase the likelihood of renal dysfunction and hyperkalemia. These interactions highlight the importance of individualized therapy and close patient monitoring.Tétel Korlátozottan hozzáférhető Quercetin unveiled: Targeting NF-κB and p53 pathways to combat Uveal MelanomaSunil, Sona; Zsebik , Barbara; Gyógyszerésztudományi Kar::Biofarmácia Tanszék; DE--Gyógyszerésztudományi Kar; Hegedűs , Éva; Fenyvesi, Ferenc; Általános Orvostudományi Kar::Biofizikai és Sejtbiológiai Intézet; Gyógyszerésztudományi Kar::Gyógyszertechnológiai TanszékUveal melanoma is the most frequently diagnosed primary intraocular tumour in adults, with metastasis occurring in nearly 50% of adults, primarily to the liver and the limited treatment options due to its chemoresistance. NF-κB and p53 are key transcription factors regulating cell survival, growth, and apoptosis. Quercetin (QUE), a naturally occurring flavonol, exhibits anti-cancer properties by activating p53 and inhibiting NF-κB signalling through suppression of IκB kinases, therefore preventing translocation to the nucleus. In this study, QUE significantly reduced uveal melanoma cell viability in a concentration-dependent manner (1–100 µM), as demonstrated by MTT assay and Bürker chamber analysis. Fluorescence imaging revealed a decrease in nuclear NF-κB intensity with a corresponding increase in the cytoplasm, while nuclear p53 intensity increased with QUE treatment (10 µM) compared to untreated, indicating altered subcellular localisation of both transcription factors. These results support the potential of QUE as a well-tolerated and effective adjunct in combination therapy for uveal melanoma.