Theses (Faculty of Pharmacy)
Állandó link (URI) ehhez a gyűjteményhez
Theses collection of the Faculty of Pharmacy. The collection was started in 2015.
At the University of Debrecen, in accordance with the 2022 amendment to the 2011 Higher Education Act, student theses are only accessible from devices connected to the University's Eduroam WiFi network or from a university IP address.
“The thesis or diploma work of a student who has successfully passed the final examination shall be stored in full in the academic system of the higher education institution, and a record shall be maintained thereof. The stored theses and diploma works – with the exception of parts classified as confidential in accordance with the relevant legislation – must be made accessible and searchable without restriction through the academic system.” Further info on the National Higher Education Act in Hungarian: Felsőokt. tv. (új) - 2011. évi CCIV. törvény a nemzeti felsőoktatásról - Hatályos Jogszabályok Gyűjteménye.
Böngészés
legfrissebb feltöltések
Megjelenítve 1 - 20 (Összesen 211)
Tétel Korlátozottan hozzáférhető Association between chemerin and advanced glycation end products in autoimmune thyroiditisTakuva, Mazvita; Berta, Eszter; Klinikai Központ; DE--Gyógyszerésztudományi Kar; A reviewer, not applicable; Klinikai KözpontThis research explores the roles both chemerin and advanced glycation end products play in inflammation and disease progression of Hashimitos disease. Advanced glycation end are formed during non enzymatic glycation of proteins. these products promote oxidative stress and immune function which may increase chemerin levels. Chemerin is an adipokine and chemokine that is involved in immune regulation and inflammation.This research suggests a positive relationship between chemerin and AGEs in autoimmune thyroiditis, where both contribute to a cycle of oxidative stress and inflammation that may influence disease progression.Tétel Korlátozottan hozzáférhető Synthesis of mannobioside containing 1,4 thio linkage for lectin binding studiesMiriam Suder, Agara; Hevesi-Mezo , Erika; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi KarMannobiosides are dimers of mannose that bind more strongly to lectins than single mannose units. They are useful for studying immune recognition, bacterial adhesion, and lectin–carbohydrate interactions. To improve stability, the glycosidic oxygen can be replaced with sulfur to form thiomannobiosides. These modified molecules remain biologically active while being more resistant to enzymatic breakdown. The thesis focuses on synthesizing a 1,4-thio-linked mannobioside using controlled chemical methods. However, the synthesis is difficult, and the final target compound was not successfully obtained.Tétel Korlátozottan hozzáférhető Synthesis of fluorine containing mannobioside for lectin binding assaysZakari , Faith; Hevesi-Mezo , Erika; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi KarThis thesis describes the synthesis of a fluorinated mannobioside as a probe for lectin–carbohydrate interactions. A fluorine atom was introduced at the C-2 position of mannose to study its effect on molecular recognition. The synthesis involved protected intermediates, triflate-mediated fluorination, and thioglycoside-based glycosylation. The target compound is intended for binding studies with mannose-specific lectins such as MBL and DC-SIGN. This work contributes to the use of fluorinated glycans as tools to investigate carbohydrate–protein interactions.Tétel Korlátozottan hozzáférhető Orvosi zsálya tartalmú önemulgeáló rendszerek fejlesztése dermális alkalmazásraKárándi, Kata; Józsa, Liza; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi KarAz orvosi zsálya (Salvia officinalis) régóta ismert gyógyhatású növény, amelynek egyik fontos hatóanyaga a karnozol, erős antioxidáns és gyulladáscsökkentő tulajdonságokkal. Ugyanakkor alacsony vízoldékonysága korlátozza hatékonyságát, ezért a kutatás célja önemulgeálódó rendszerek (SNEDDS) fejlesztése volt a biológiai hozzáférhetőség javítására. Az így létrehozott rendszerek megfelelő fizikai stabilitást mutattak, kis cseppmérettel és kedvező eloszlási tulajdonságokkal. A hatóanyagot tartalmazó krémek vizsgálata során igazolták a jó felszabadulást és bőrön való áthatolást, valamint a megfelelő biokompatibilitást. Az in vitro tesztek jelentős antioxidáns és gyulladáscsökkentő aktivitást mutattak, különösen a SNEDDS-t tartalmazó formulációk esetében. Az eredmények ígéretesek a helyi alkalmazású zsálya-alapú készítmények fejlesztésében, bár további vizsgálatok szükségesek a klinikai alkalmazhatóság megerősítéséhez.Tétel Korlátozottan hozzáférhető The classification and the therapy of musculoskeletal disordersErol, Berk; Fehér, Pálma; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Priksz, Daniel; Ujhelyi, Zoltán; Általános Orvostudományi Kar; Gyógyszerésztudományi KarMusculoskeletal disorders (MSDs) have a wrong dichotomy in a passive mechanical form--a mechanical “wear and tear.” Nowadays, it has been shown that they are sustained along dynamic pathobiochemical pathways such as NF-κB-mediated inflammation and extracellular matrix fragmentation via matrix metalloproteinases (MMPs), and oxidative stress on bone, cartilage, tendon, and skeletal muscles.The goal is to merge various mechanisms of inflammatory processes for diverse MSDs -- osteoarthritis and rheumatoid arthritis, sarcopenia and tendinopathy -- from the level of molecular biology. I also aim here to review a pharmacologic mechanism in the treatment of these conditions. This review will detail the efficacy, safety, and pharmacokinetics of both new therapeutic paradigms and then summarize the pharmacognostic evolutionary steps of these, starting with ethnobotanical initiation, leading up to synthetic drugs. Medications such as allopathic (NSAIDs, corticosteroids, and targeted biologic DMARDs) provide unparalleled fast analgesia and acute disease suppression with high-affinity, single target inhibition effect. Systemic toxicities and iatrogenic effects vary widely by dose and restrict their chronic use, however. On the other hand, these standardized species (Curcuma longa, Boswellia serrata, and Withania somnifera) exhibit pleiotropy. They also have a dual anti-inflammatory action against different inflammatory pathways (COX, 5- LOX, NF-κB) eventually also have this drug-sparing drug effect as well, due to their much superior chronic safety profile with a lower toxicity; however their delayed course, and possibly more associated with a potential for cytochrome P450 interaction are drawbacks. MSDs with a course of progressive disease will not respond to monotherapy. I presented an evidence-based, synergistic pharmacological model as an integrative, pharmaceutical solution for this thesis. By maximizing the effectiveness of synthetic agents to promote remission and treatment of acute flares, and transitioning to new high-grade, standardized botanical modulators to maintain physiological maintenance, clinicians can work toward the biochemical levers for joint and muscle disease, by eliminating the biochemical drive forces behind these diseases and utilizing synthetic properties for the long term benefit of treatment and the most efficient longevity.Tétel Korlátozottan hozzáférhető Comparative analysis of adverse event profiles of original biologics vs. biosimilars in the treatment of HER-2 positive breast cancerBol , Rebecca Mekalilie Benjamin; Horvath , Laszlo; DE--Gyógyszerésztudományi Kar; Fenyvesi , Ferenc; Ujhelyi, ZoltánThis thesis investigates the safety profiles of HER2-targeted biologics, focusing on trastuzumab and its biosimilars using real-world pharmacovigilance data. It compares reported adverse drug reactions between the originator product and its biosimilars. The most commonly reported adverse events were consistent with known effects of HER2-targeted therapies and their combination with chemotherapy. While there was a high degree of overlap in safety profiles, some differences in reported reactions were observed. Overall, the findings support comparable safety between biologics and biosimilars, while emphasizing the need for continued post-marketing surveillance.Tétel Korlátozottan hozzáférhető ADVANCES IN PHARMACEUTICAL BIOTECHNOLOGY FOR CANCER TREATMENT: THE CONTRIBUTION OF MONOCLONAL ANTIBODIES AND GENE THERAPYNguyen, Ngoc Thuy Anh; Zsebik, Barbara; Gyógyszerésztudományi Kar::Biofarmácia Tanszék; DE--Gyógyszerésztudományi Kar; Fenyvesi, Ferenc; Korpos, Éva; Gyógyszerésztudományi Kar; Gyógyszerésztudományi KarThis thesis provides a comprehensive review of the role of pharmaceutical biotechnology in advancing cancer treatment, with a focus on precision oncology. It examines two principal therapeutic strategies: monoclonal antibodies, which enable targeted recognition of tumor-associated antigens, and gene-based therapies designed to enhance anti-tumor immune responses. Particular emphasis is placed on chimeric antigen receptor T-cell (CAR-T) therapy, including its clinical success in hematological malignancies and ongoing research aimed at its application in solid tumors, as well as tumor-infiltrating lymphocyte (TIL) therapy. In addition, the thesis highlights the increasing importance of nanotechnology and nanoparticle-based delivery systems in improving therapeutic specificity and stability. Despite current limitations, such as high production costs and challenges in tumor penetration, these approaches demonstrate considerable potential. Overall, the findings underscore the transformative impact of biotechnological innovations in the development of personalized cancer therapies.Tétel Korlátozottan hozzáférhető Antifungal Susceptibility and Species Distribution of Dermatophytes Isolated at the University of Debrecen.Guchu, Maryanne; Zoltán, Tóth; Általános Orvostudományi Kar::Orvosi Mikrobiológiai Intézet; DE--Gyógyszerésztudományi Kar; Nagy, Fruzsina; Lekli, István; Általános Orvostudományi Kar::Orvosi Mikrobiológiai Intézet; Gyógyszerésztudományi KarDermatophyte infections affect approximately one quarter of the global population. While these infections are not life-threatening, they can significantly impact quality of life. Recently, substantial changes in the epidemiology of dermatophyte infections have been observed worldwide, including increasing reports of antifungal resistance and the emergence of novel species causing extensive, often therapy-refractory disease. Since no local epidemiological data are available, this study aimed to examine the species distribution and antifungal susceptibility of dermatophytes isolated at the Department of Medical Microbiology.Tétel Korlátozottan hozzáférhető Drug utilization and adverse drug reactions of semaglutideGhaly, Nabil Adel; Horváth , László; Gyógyszerésztudományi Kar::Gyógyszerfelügyelet és Gyógyszergazdálkodási Tanszék; DE--Gyógyszerésztudományi KarThis thesis provides a comprehensive evaluation of the drug utilization patterns and adverse drug reactions associated with semaglutide across multiple international settings. By integrating pharmacoepidemiological metrics with pharmacovigilance data from FAERS and EudraVigilance, the study offers a robust real-world assessment of both utilization trends and safety profiles. The findings demonstrate a consistent increase in semaglutide use over time, alongside a well-characterized spectrum of reported adverse drug reactions, predominantly gastrointestinal in nature. The analysis further explores demographic and reporting variations, including differences by sex, age, and reporter type. Overall, the study contributes meaningful evidence to the understanding of semaglutide’s real-world application and its implications for clinical practice and public health.Tétel Korlátozottan hozzáférhető Estimation of Renal Function For Antibiotic Dosing DesicionsMohammadiKhabbaz, Ghazal; Fésüs, Adina; Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; DE--Gyógyszerésztudományi Kar; Lekli, István; Horváth, László; Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; Gyógyszerésztudományi Kar::Gyógyszerfelügyelet és Gyógyszergazdálkodási TanszékThe overall goal of our study is to provide evidence through specific clinical examples on how accurate recognition and correction of the errors in antibiotic prescription can lead to a significant reduction of Antibioic use. We will evaluate the dose of antibiotics considering kidney function. We are interested in whether the dosage included in the SPC recommendations according to the estimated creatinine clearance (Generally using the CG equation fr patients over 18 years of age).Tétel Korlátozottan hozzáférhető The Role of Hydrogen Sulfide Treatment in Doxorubicin-Induced CardiotoxicityPHAN, LE BAO NHI; Lekli, István; Eskeif, Simon; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Balázs, Varga; Miklós, Imre Vecsernyés; Somodi, Sandor; Általános Orvostudományi Kar; Gyógyszerésztudományi Kar; Általános Orvostudományi KarDoxorubicin is an effective anticancer drug, but its clinical use is limited by cardiotoxicity caused by oxidative stress, mitochondrial dysfunction, and apoptosis in cardiomyocytes. Hydrogen sulfide (H₂S) has been identified as a potential cardioprotective molecule due to its antioxidant and cytoprotective properties. This study investigated the effects of EV-34, a fast-releasing H₂S donor, in a doxorubicin-induced cardiotoxicity model using H9c2 cells. EV-34 increased intracellular H₂S levels, improved cell viability, and reduced mitochondrial oxidative stress in doxorubicin-treated cells. It also enhanced AMPK activation, while its effect on apoptosis-related proteins was not statistically significant. Overall, EV-34 demonstrates potential cardioprotective effects in vitro; however, further in vivo studies are required to confirm its therapeutic relevance.Tétel Korlátozottan hozzáférhető Biological studies of heterobimetallic complexes as hypoxia-activated anticancer prodrugsEigbe, Ehiremhen Yvonne; Sipos, Éva; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Haimhoffer, Adam; Varga, Balázs; Gyógyszerésztudományi Kar; Általános Orvostudományi KarCancer remains a major cause of death worldwide, and while Pt(II) drugs like cisplatin are effective, their lack of selectivity leads to significant side effects. To address this, researchers are exploring alternative metal complexes with better targeting, such as Co(III) compounds that act as hypoxia-activated prodrugs. These complexes remain inactive in normal oxygen conditions but become activated in the low-oxygen environment of tumors, releasing a cytotoxic ligand derived from the iron chelator Deferiprone. In this study, newly synthesized Co(III)-based complexes and the ligand were tested on MCF-7 breast cancer cells under both normoxic and hypoxic conditions using cytotoxicity assays and RT-qPCR. Results showed that the Co(III) complex exhibited selective activation under hypoxia, with reduced toxicity in normal conditions, while the ligand induced gene expression consistent with iron chelation. Overall, the findings suggest that Co(III) complexes could serve as targeted carriers for anticancer agents, and iron chelators may also have therapeutic potential.Tétel Korlátozottan hozzáférhető Biological studies of iron chelating agent KN1 and cobalt containing complex KNK 0.1 as hypoxia-activated anticancer prodrugsPhan Trung, Phuong; Sipos, Éva; Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; DE--Gyógyszerésztudományi Kar; Pető, Ágota; Homolya, Ágnes; Gyógyszerésztudományi Kar; Gyógyszerésztudományi Kar::Gyógyszerészi Kémiai TanszékThis research explores (PGM, Co(III)) heterobimetallic complexes as a targeted alternative to traditional Pt(II) therapies like cisplatin, which are often limited by systemic toxicity and drug resistance. The study specifically evaluates KN1 (DTBC), an iron-chelating ligand, and KNK 0.1 (Co(tren)DTBC), a cobalt-based prodrug designed for selective activation. Using two-way ANOVA for data analysis, the drugs were tested against the MCF-7 breast cancer cell line across 24-hour and 72-hour intervals under both normoxic and hypoxic conditions. Results indicated that while KN1 exhibits moderate cytotoxicity, KNK 0.1 effectively functions as a hypoxia-activated anticancer prodrug, releasing its cytotoxic payload specifically in oxygen-deficient environments. Ultimately, this work demonstrates the potential of cobalt-containing complexes to improve tumor selectivity and reduce the side effects typically associated with conventional chemotherapy.Tétel Korlátozottan hozzáférhető Microneedle-Assisted Transdermal Drug delivery systems: material, design and skin interactionShojaei, Yalda; Peto, Agota; DE--Gyógyszerésztudományi KarMicroneedle transdermal patches are explored as a promising alternative to traditional drug delivery methods. The structure of the skin and the limitations of conventional transdermal patches and injections have been reviewed to highlight the need for new approaches. The design, materials, drug-loading strategies, and release mechanisms of microneedles are discussed to explain how they can effectively deliver drugs through the skin while remaining comfortable for patients. Depending on their design, these systems can provide immediate, sustained, or stimulus-responsive drug release. Microneedles also have a wide range of applications, including vaccination, diabetes management, hormone delivery, cancer therapy, and cosmetic treatments, with increasing interest in personalized medicine. Overall, they represent a promising step forward in drug delivery, although further research is still needed for wider clinical and commercial use.Tétel Korlátozottan hozzáférhető Formulation and evaluation of a tipical preparation containing RoflumilastMahdavi, Mahyar; Pető, Ágota; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; DE--Gyógyszerésztudományi Kar; Bácskay, Ildikó; Bak, Istvan; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; Gyógyszerésztudományi Kar::Gyógyszerhatástani TanszékPsoriasis is a chronic, proliferative, inflammatory dermatologic disease that accelerates the skin cell proliferation rate from 26-28 days to 3-4 days, resulting in increased skin thickness and cutaneous plaques. Its symptoms are red lesions with white scales and silver colored flakes, accompanied by a burning sensation and pruritus. The most common type of psoriasis is Plaque Psoriasis; topical agents are also the best therapeutic approach in the case of Mild-to-Moderate Plaque Psoriasis. Roflumilast is a selective phosphodiesterase-4 (PDE-4) inhibitor that was approved as a topical agent in the case of mild-to-moderate plaque psoriasis by the U.S. Food and Drug Administration (FDA). Its mechanism of action in this skin disease is not yet fully understood, but it likely provides anti-inflammatory effects. This paper aimed to formulate and evaluate a nanogel containing Roflumilast. Two gel compositions were prepared with and without hydroxypropyl-beta-cyclodextrin (HPBCD). Physicochemical characterization included pH measurement, rheological analysis, particle size analysis, and in vitro drug-release studies. Both nanogels showed acceptable values in the case of pH measurements. Rheology analysis confirmed shear-thinning behavior, which is favorable for topical preparations. Particle size analysis demonstrated smaller values for the nanogel containing Roflumilast and HPBCD compared to the nanogel containing Roflumilast. An in-vitro drug release study indicated higher drug release in the case of the nanogel containing Roflumilast and HPBCD. In conclusion, Roflumilast nanogels were successfully formulated and showed suitable physicochemical properties for topical use. The incorporation of HPBCD increased the solubility of Roflumilast in Tween 80, reduced particle size, and enhanced drug release.Tétel Korlátozottan hozzáférhető The relationship between alcohol consumption and antidepressant use in some European countriesAhmed , Mohamed; László, Horváth; Gyógyszerésztudományi Kar::Gyógyszerfelügyelet és Gyógyszergazdálkodási Tanszék; DE--Gyógyszerésztudományi Kar; Váradi, Judit; Fenyvesi, Ferenc; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; Gyógyszerésztudományi Kar::Gyógyszertechnológiai TanszékAlcohol consumption and depression have become one of the great public health challenges facing the world and they are directly related to biological, psychological and social means. Antidepressants are one of the most frequently administered classes of drugs to treat depressive disorders, and particularly in high income European countries.Tétel Korlátozottan hozzáférhető Evaluation Of The Antiproliferative Effects Of Newly Synthesized Cyclodextrin DerivativesMai, Fatima Aminu; Ferenc, Fenyvesi; DE--Gyógyszerésztudományi KarThe thesis focuses on the application of cyclodextrin in enhancing the effect of Fluorouracil on HCT116 and Caco-2 cell lines. The study was designed to evaluate the potential effectiveness and interactions of these compounds in a controlled in vitro environment. The methodology used was appropriate for the research objectives and allowed for reliable and reproducible results. The findings contribute to a better understanding of how cyclodextrin can improve drug delivery. Some limitations were encountered but they did not affect the overall outcome of the study. Overall this work demonstrates the relevance of the topic and provides a foundation for further research in anticancer drug development.Tétel Korlátozottan hozzáférhető Biocompatibility and bioavailability studies of a vaginal gel containing hydroxypropyl-beta-cyclodextrin complexesTorabi Mousavi, Seyedhadi; Fenyvesi, Ferenc; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Horváth, László; Arany, Petra; Gyógyszerésztudományi KarVaginal gels are widely used for the treatment of local vaginal infections, contraception, and the symptoms of menopause. Hormone replacement therapy can be an efficient method for the treatment of menopausal symptoms, and the local application of low-dose estrogen hormones in the vagina improves the safety of the therapy. Our aim is to test an estrogen hormone-containing vaginal gel, which contains estrogens in a hydroxypropyl-betacyclodextrin (HPβCD) complex. Estrogens are insoluble in water; however, their complexation with HPβCD improves its water solubility and bioavailability in the vaginal environment. HPβCD is a widely used cyclic oligosaccharide, improves the solubility of poorly soluble drugs, considered to be safe and non-toxic but the vaginal application of this excipient has not been studied yet. The work aims at testing the vaginal gel on HaCat keratinocyte cell line and SkinEthicTM HVE / Human Vaginal Epithelium model for biocompatibility and toxicity studies. MTT and LDH tests are used for the determination of the toxicity of the gel and its components on the cell line and the vaginal model. The Human Vaginal Epithelium model is also used for determining the amount of estriol permeated through the epithelial cell layers. The effect of the HPβCD -complex on cell proliferation was examined by a wound-healing assay, which may provide new information about the tissue regenerative effects of the complex. The study helps to obtain new data about the safety and efficacy of the vaginal application of HPβCD and its estrogen complex.Tétel Korlátozottan hozzáférhető Manufacturing of theophylline-containing hydrophilic matrix tablets and the effect of formulation variation and granulation type on the diameter/height ratio.Saadati, Sanaz; Arany , Petra; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; DE--Gyógyszerésztudományi Kar; Gonda , Sándor; Bege , MiklósThis thesis investigates the manufacturing of theophylline-containing hydrophilic matrix tablets, focusing on the effect of formulation and granulation methods on tablet properties. Direct compression was unsuccessful due to poor flowability and compressibility, leading to the use of wet granulation. However, Carbopol® 71G caused excessive stickiness, which was resolved by replacing it with Carbopol® 974P. Since wet granulation did not provide sufficient mechanical strength, hot-melt granulation was applied as an alternative. This method produced denser granules and tablets with improved hardness and stability. Overall, the results demonstrate that granulation technique and formulation composition play a critical role in successful tablet development.Tétel Korlátozottan hozzáférhető Exploring PD-L1 and PD-L2 as Possible Biomarkers in Renal CancerSEYED PIRAN, SEYED BEHRAD; Szabó , Zsuzsanna; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Dobos, Nikoletta; Szabó, Erzsébet; Gyógyszerésztudományi KarThis study explores how two proteins, PD-L1 and PD-L2, may help predict treatment results in people with kidney cancer, specifically renal cell carcinoma (RCC). Researchers compared cancer tissue and nearby healthy kidney tissue from 20 patients and found both proteins were expressed more in tumors. Especially in aggressive tumors (Grade 4), PD-L1 and PD-L2 levels were much higher, suggesting a link between these proteins and tumor severity. One case showed unusually high PD-L1 even in a less aggressive tumor, hinting at differences between individual tumors. The findings suggest that targeting both proteins could improve treatment results, especially for high-risk patients. The study supports the use of these proteins to better match patients with the right immune therapy.