Psoriasis is one of the most common immune-mediated skin diseases. Although its pathomechanism has been extensively studied, there are still unexplored areas. The crucial role of skin-resident dendritic cells (DCs) in the development and maintenance of the disease has long been recognized. However, the characteristics and functions of one of their presumed precursors - the blood-circulating DCs - have not yet been fully elucidated. Therefore, we examined the activity of circulating DCs (myeloid and plasmacytoid DCs) in the blood of patients with psoriasis, as well as their cytokine and chemokine production. We have found that psoriatic blood mDCs are in an early maturation phase and are capable of producing Th1 type cytokines (IL-12) and inflammatory chemokines (CXCL9, CCL20, CXCL8 and CXCL10). These findings suggest that not only skin DCs, but also their blood precursors can serve as potential source of cytokines and chemokines, since CD1c+ mDCs in psoriatic patients possess an increased potential to produce disease-specific mediators even in the peripheral blood. On the other hand, pDCs appear to be functionally inactive in the bloodstream, suggested by the lack of maturation/activation markers and their functional inactivity. According to these results blood pDCs’ activation primarily occurs within the skin microenvironment. The sebaceous gland-rich and gland-poor regions of healthy skin are characterised by different physical, chemical, microbiological and immunological barriers. This may contribute to the fact that certain immune-mediated skin diseases are localised to certain skin regions, such as atopic dermatitis, which is a disease of the gland-poor regions, or rosacea, which is a disease of the sebaceous gland-rich regions. There are also skin diseases such as psoriasis, which affects both gland poor (psoriasis vulgaris) and sebaceous (scalp psoriasis) regions. We compared the cellular and molecular immune characteristics of psoriasis vulgaris in SGP skin and scalp psoriasis to investigate, whether the immune characteristics of the two subtypes of psoriasis are influenced by the specific immune milieu of the skin regions where they develop. We studied the disease-specific innate and adaptive immune cells, the expression of Th1/Th17 related cytokines, chemokines, AMPs, and barrier-related molecules at mRNA and protein levels. We have found that both innate immune responses, Th1/Th17 adaptive immune pathways and the expression of barrier molecules are similar in psoriasis vulgaris and scalp psoriasis, since we could detect only some minor differences between the two conditions. According to our results psoriasis localised to different skin parts share similar IL-17 related immune characteristics, therefore to develop active ingredients with different mechanisms-of-action for psoriasis vulgaris and scalp psoriasis is unnecessary.