The thesis titled “Pharmacological Therapy of Acne Vulgaris” explores the causes, types, and modern treatments of acne. It describes acne as a persistent inflammatory disorder of the skin’s pilosebaceous unit, mainly influenced by hormones, bacteria, and immune activity. The research reviews both topical medications—such as retinoids, benzoyl peroxide, and antibiotics—and systemic options, including oral antibiotics, hormonal agents, and isotretinoin, with attention to their actions and side effects. It emphasizes the value of evidence-based, personalized therapy guided by international recommendations. The study also addresses treatment considerations during pregnancy, the emotional and psychological burden of acne, and the issue of antibiotic resistance. Finally, it highlights innovative approaches like microbiome-focused therapy, probiotics, and nanotechnology as promising directions for future acne management.