Role of AtfA transcription factor in the cellular defense against nitrosative stress in Aspergillus spp.

A tétel rövid nézete
dc.contributor.advisorHaas, Hubertus
dc.contributor.advisorPócsi, István
dc.contributor.advisordeptDebreceni Egyetem:Természettudományi és Technológiai Karhu_HU
dc.contributor.advisordeptInnsbrucki Orvosi Egyetem, Biocenter, Molekuláris Biológia Divízió (Ausztria, A-6020, Innrain 80.)hu_HU
dc.contributor.authorSzaniszló, Szilvia
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentPusztahelyi, Tünde
dc.contributor.opponentdeptDebreceni Egyetem::Természettudományi és Technológiai Karhu_HU
dc.contributor.opponentdeptAgrárműszer Központhu_HU
dc.date.accessioned2017-02-07T09:34:25Z
dc.date.available2017-02-07T09:34:25Z
dc.date.created2016
dc.description.abstractA. fumigatus is the most important airborne human fungal pathogen, which can cause severe invasive pulmonary aspergillosis in immunocompromised patients. Understanding of oxidative and nitrosative stress responses in pathogenic fungus is substantial and can contribute to explain pathogenicity. While AtfA transcription factor has already been described to be involved in oxidative stress response in Aspergilli, not much is known with regards to nitrosative stress response. The aim of this study was to determine the putative role of AtfA transcription factor in nitrosative stress response in A. fumigatus. High sensitivity of the ΔatfA mutant strain was discovered in growth assay experiments which suggest a significant role in regulation of resistance to nitrosative stress in A. fumigatus. AtfA transcription factor may take part in regulation throws new light upon NO detoxification in Aspergillus spp.hu_HU
dc.description.coursemolekuláris biológiahu_HU
dc.description.courseactnappalihu_HU
dc.description.courselangmagyarhu_HU
dc.description.coursespecGenetikahu_HU
dc.description.degreeMSc/MAhu_HU
dc.format.extent45hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/234989
dc.language.isoenhu_HU
dc.subjectAspergillushu_HU
dc.subjectAtfAhu_HU
dc.subjectnitrosative stresshu_HU
dc.subject.dspaceDEENK Témalista::Biológiai tudományokhu_HU
dc.titleRole of AtfA transcription factor in the cellular defense against nitrosative stress in Aspergillus spp.hu_HU
dc.title.translatedAz AtfA transzkripciós faktor szerepe Aspergillus fajokban a nitrozatív stresszel szembeni védelem soránhu_HU
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Gyűjtemények
Hallgatói dolgozatok (Általános Orvostudományi Kar)