Investigation of fluorinated CBD derivatives protective effects against Doxorubicin cardiotoxicity

Abstract

The thesis aims to investigate the newly synthesized, fluorinated CBD derivatives on their protective effect against cardiotoxicity induced by Doxorubicin, a well-known chemotherapeutic agent. Several tests were carried out, such as antioxidant assays, MTT assay, MitoSOX staining and Western blot analysis. Antioxidant capacity of the derivatives were thoroughly studied, since the elevation of oxidative stress is one of the major mechanisms of Doxorubicin. The results suggested that the flourinated derivatives, especially molecule 17, showed a higher cell viability, better antioxidant effect and thus better cardioprotection, comparing to CBD. However, further research is required to ensure the safety and effect of the compounds.