The role of HCN2 in macrophage cytokine release

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dc.contributor.advisorUray, Karen Lee
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Orvosi Vegytani Intézet
dc.contributor.authorFrangu, Rrezon
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.contributor.opponentKoncz, Gábor
dc.contributor.opponentdeptÁltalános Orvostudományi Kar::Immunológiai Intézet
dc.date.accessioned2024-06-04T07:49:27Z
dc.date.available2024-06-04T07:49:27Z
dc.date.created2024-06-02
dc.description.abstractThis study explores the role of hyperpolarization-activated cyclic nucleotide-gated HCN channels in macrophage inflammation and their potential impact on intestinal motility. While HCN2 inhibition is known to decrease intestinal motility, its involvement in the development of ileus remains unclear. The research focused on HCN channels, particularly HCN2, which are crucial for cellular excitability and pacemaking, and are now recognized for their role in immune modulation. THP1 cells were treated with the HCN channel blocker ZD7288 or a vehicle control (DMSO) and subjected to cyclic stretch, with cytokine release measured to assess inflammation. Using the FlexCell system to apply mechanical stretch to activated THP1 cells, results showed a significant reduction in macrophage cytokine release following HCN2 inhibition. These findings enhance our understanding of HCN2 channels in macrophage inflammation and suggest their potential as therapeutic targets.
dc.description.coursemolekuláris biológia
dc.description.courselangangol
dc.description.coursespecImmunológia, sejt- és mikrobiológia
dc.description.degreeMSc/MA
dc.format.extent35
dc.identifier.urihttps://hdl.handle.net/2437/370862
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjecthcn2 channels
dc.subjectmechanical stretching
dc.subjectintestinal motility
dc.subjectcytokine release
dc.subject.dspaceBiology::Molecular Biology
dc.titleThe role of HCN2 in macrophage cytokine release
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