Synthesis and Microwave-Assisted Pathways of 6-Iodo- Benzoflavanone Derivatives

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dc.contributor.advisorKurtán, Tibor
dc.contributor.authorEmara, Fatma
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Kémiai Intézet
dc.date.accessioned2024-12-17T08:22:07Z
dc.date.available2024-12-17T08:22:07Z
dc.date.created2024-11-15
dc.description.abstractMy thesis explores the synthesis of 6-iodo-4’-(trifluoromethyl)-7,8-benzoflavanone, focusing on its potential as aromatase inhibitor to aid in breast cancer treatment. The thesis outlines two synthetic pathways: microwave-assisted and base-catalyzed, each employing multiple reaction steps to optimize yields and reaction efficiency. Starting from hydroxyacetophenone derivatives, the synthetic process includes key steps like Friedel-Crafts acylation, Claisen-Schmidt condensation, and cyclization, achieving varying yields across methods, structures were confirmed using NMR spectroscopy. The study emphasizes the microwave-assisted approach for its efficiency and reduced reaction time, aligning with green chemistry principles. Ultimately, the synthesized benzoflavanone derivatives serve as standards for stereoselective reactions, with successful enantioselectivity applications promising for drug development.
dc.description.courseBiochemical engineering
dc.description.degreeBSc/BA
dc.format.extent30
dc.identifier.urihttps://hdl.handle.net/2437/383189
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectFlavanones
dc.subjectAromatase inhibtion
dc.subjectMicrowave-assisted synthesis
dc.subjectBase-catalyzed synthesis
dc.subjectCyclization
dc.subjectEnantioselectivity
dc.subject.dspaceChemistry
dc.titleSynthesis and Microwave-Assisted Pathways of 6-Iodo- Benzoflavanone Derivatives
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