Migraine headache is a widespread neurovascular disorder that is often inadequately treated by existing medical therapies, resulting in a population of patients with significant residual disability. Treatment strategies include educational interventions, lifestyle modifications, and trigger management, as well as acute and preventive pharmacotherapy. Objectives: the aim of this work is to identify the advances in treatment of migraine.We found that the most famous drug used in migraine treatment is triptan. And found also that most of patients are non-responsive to a triptan at 2 h after treatment onset, or do not tolerate existing acute treatment options, including triptans.So new drugs are discovered for treatment of migraine like CGRP, Serotonin 5HT1F agonists, Glutamate receptor antagonists, etc.