This thesis provides a comprehensive analysis of post-mortem drug metabolism, emphasizing the challenges posed by post-mortem redistribution (PMR). It effectively examines the factors influencing drug concentration changes after death and evaluates advanced analytical techniques such as GC-MS and LC-MS. The discussion on different drug classes, including opioids, stimulants, and antidepressants, enhances the forensic understanding of toxicological findings. The research highlights the complexities of interpreting post-mortem toxicology results and the importance of accurate sampling. The study’s forensic applications are well-explored, offering valuable insights into cause-of-death determinations. Overall, it is a well-structured and informative contribution to forensic pharmacology.