With epilepsy being one of the most common neurological disorders, there is constant research hoping to find the most ideal antiepileptic drug therapy. Among the new antiepileptic drugs that exist today, the majority are used as an add-on therapy in combination with a standard therapy. Levetiracetam and Zonisamide are two of the newer drugs, each possessing its own unique features, that are widely used for partial as well as generalized epileptic seizures.