Genetic and structural alterations of dentin: dentinogenesis imperfecta and dentin dysplasia

A tétel rövid nézete
dc.contributor.advisorKovalecz, Gabriella
dc.contributor.advisordeptDebreceni Egyetem::Gyermeknevelési és Gyógypedagógiai Kar
dc.contributor.authorKurexi, Xuliya
dc.contributor.departmentDE--Fogorvostudományi Kar
dc.contributor.opponentNemes, Judit
dc.contributor.opponentKapusi-Papp, Zsuzsa
dc.contributor.opponentdeptDebreceni Egyetem::Gyermeknevelési és Gyógypedagógiai Kar
dc.date.accessioned2023-05-02T06:13:03Z
dc.date.available2023-05-02T06:13:03Z
dc.date.created2023-03-05
dc.description.abstractInherited dentine diseases, such as dentinogenesis imperfecta (DGI) and dentine dysplasia (DD) and their several subtypes, which are classified by Shield , based on clinical and radiological similarities, are genetic disorders that can affect the primary and secondary dentitions. Patients with DGI type I may have mutations in the COL1A2 or COL1A1 genes, whereas those with DGI types II and III and DD type II may have mutations in the DSPP gene. Additionally, mutations in the SMOC2, VPS4B, and SSUH2 genes have been associated with DD type I. Inherited dentin disorders often affect primary teeth more severely than permanent teeth, and the symptoms are usually noticeable at an early age. DGI causes yellowish-brown teeth with constricted cervical areas and wide crowns, while DD presents normal enamel formation and color, with short and blunted roots, and pulp cavities that may have a thistle-tube deformity and pulp stones commonly. These conditions can cause significant attrition, loss of dentition, and aesthetic effects on patients, leading to low self-esteem, dental anxiety, and poor quality of life.
dc.description.correctorLB
dc.description.coursefogorvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent35
dc.identifier.urihttps://hdl.handle.net/2437/351353
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjecthereditary dentin disorders
dc.subjectdentinogenesis imperfecta
dc.subjectdentin dysplasia
dc.subject.dspaceDEENK Témalista::Orvostudomány
dc.titleGenetic and structural alterations of dentin: dentinogenesis imperfecta and dentin dysplasia
Fájlok
Gyűjtemények
Theses (Faculty of Dentistry)