Theses (Faculty of Dentistry)
Állandó link (URI) ehhez a gyűjteményhez
Theses collection of the Faculty of Dentistry. The collection was started in 2015.
At the University of Debrecen, in accordance with the 2022 amendment to the 2011 Higher Education Act, student theses are only accessible from devices connected to the University's Eduroam WiFi network or from a university IP address.
“The thesis or diploma work of a student who has successfully passed the final examination shall be stored in full in the academic system of the higher education institution, and a record shall be maintained thereof. The stored theses and diploma works – with the exception of parts classified as confidential in accordance with the relevant legislation – must be made accessible and searchable without restriction through the academic system.” Further info on the National Higher Education Act in Hungarian: Felsőokt. tv. (új) - 2011. évi CCIV. törvény a nemzeti felsőoktatásról - Hatályos Jogszabályok Gyűjteménye.
Böngészés
legfrissebb feltöltések
Megjelenítve 1 - 20 (Összesen 431)
Tétel Embargó alatt Preparation and characterization of PEGDMA-based 3D printable hydrogels with customizable properties using NVP additiveTrung Hieu, Nguyen; Bakó, József; Fogorvostudományi Kar::Bioanyagtani és Fogpótlástani Nem Önálló Tanszék; DE--Fogorvostudományi KarIn this study, poly(ethylene glycol) dimethacrylate (PEGDMA) hydrogels containing varying concentrations (20% to 45%) of N-vinyl-2-pyrrolidone (NVP) were successfully fabricated using stereolithography (SLA) 3D printing. Mechanical testing revealed that increasing the NVP concentration transitions the hydrogels from a ductile state to a stiffer, more brittle material, with the compressive Young’s modulus peaking at 13.15 MPa at 35% NVP. Swelling behavior was also highly dependent on NVP levels; formulations with lower concentrations hydrated rapidly within an hour, whereas higher NVP concentrations required up to 24 hours to reach equilibrium. Fourier-transform infrared (FT-IR) spectroscopy confirmed effective polymerization across all samples, and contact angle measurements verified that every formulation maintained strong hydrophilic properties. Ultimately, this research demonstrates that modifying NVP concentrations in PEGDMA hydrogels allows for precise tuning of their mechanical and physical characteristics. Because they are compatible with commercial SLA printers, these customizable materials hold significant promise for diverse biomedical and dental applications, including soft tissue scaffolds, periodontal barriers, and drug delivery systems.Tétel Embargó alatt Serum and Salivary Nerve Growth Factor As a Potential Biomarker in Oral MucositisHuang, xufeng; Gebri, Enikő Zsuzsa; Fogorvostudományi Kar; DE--Fogorvostudományi Kar; Fogorvostudományi KarBackground: Nerve growth factor (NGF) plays essential roles in epithelial repair, neuro-immune signalling, and inflammatory pain. However, its dynamic changes during autologous peripheral stem cell transplantation (APSCT) and the relationship to transplant-related mucosal and systemic injury remain poorly understood. The present study aimed to characterize longitudinal alterations in salivary and serum NGF levels during APSCT and to compare them with age-sex matched healthy controls. Materials and Methods: Ten patients with malignant hematological diseases undergoing APSCT were enrolled. Salivary and serum NGF concentrations were measured at four clinically relevant time points: pre-conditioning (Day −3/−7), transplantation day (Day 0), early post-transplant nadir (Day +7), and mucosal recovery phase (Day +14). Healthy controls included volunteers aged 25–34 (n=9), 35–59 (n=7), and ≥60 years (n=7). NGF levels were quantified by ELISA and compared across stages and age groups. Results: Both salivary and serum NGF in APSCT patients showed elevation, with significant increases at Day 0 and a second, more pronounced peak at Day +7, followed by a decline toward recovery by Day +14. This NGF surge paralleled the expected trajectory of conditioning-induced tissue injury and peak post-transplant mucositis. In healthy controls, NGF concentrations in both serum and saliva decreased with age, with the ≥60-year group exhibiting significantly lower baseline levels than younger groups. Conclusions: APSCT induces marked and stage-specific elevations in NGF, likely reflecting acute chemotherapeutic injury, inflammation-driven neuro-immune activation, and subsequent tissue repair responses. The second NGF peak at Day +7 coincides with the nadir phase and the period of greatest mucosal damage, suggesting a potential role for NGF as a biomarker of transplant-related mucosal and systemic stress. Together, these findings highlight NGF as a promising candidate for monitoring tissue injury and recovery in APSCT.Tétel Embargó alatt Effects of different aging methods on the repair bond strengths of short fiber reinforced compositeNGUYEN PHUONG, VY; MARTOS, RENÁTA; Fogorvostudományi Kar::Konzerváló Fogászati nem önálló Tanszék; DE--Fogorvostudományi KarIn contemporary restorative dentistry, short-fiber reinforced composite (SFRC) frequently serves as a dentin replacement material. However, its mechanical limitations within the harsh oral environment often necessitate restorative repairs over time. Because validating the durability of these repairs requires artificial aging methods that accurately mimic intraoral conditions, this study evaluates and compares the effects of thermocycling and long-term water storage on microtensile repair bond strength. The comprehensive in vitro methodology encompassed specimen preparation, surface treatment, composite repair, load testing, artificial aging, and subsequent statistical analysis of the bond strength. Results demonstrated no statistically significant differences in microtensile bond strength between the two aging methods. Consequently, thermocycling is established as the superior experimental protocol, offering a reliable assessment of SFRC repair durability within a significantly condensed timeframe.Tétel Korlátozottan hozzáférhető Wettability of resin matrix of dental composite by different liquidsLuu, Chau Anh; Szalóki, Melinda; Fogorvostudományi Kar; DE--Fogorvostudományi KarThe aim of this study is to investigate the effect of surface roughness and chemical composition of polymerized resin composites of wetting of water, organic solvents (acetone, ethanol), and aqueous solution of phosphoric acid (37 m/m% H₃PO₄). The tested composites were Estelite Asteria (EA), Clearfil Majesty (CM), Enamel Plus Hri Bio Function (EBF), EverX (EX), NeoSpectra (NS), Smart Dentin Replacement (SDR), and Tetric EvoCeram Bulk Fill composite (TECBF). The highest CA was found by H3PO4, then water, due to structure making effect of the acid. The lowest CA was found with acetone, then ethanol. The wettability of resin-rich composite is more preferable for acetone than ethanol, explained by the polarity of the organic solvent molecule. The Ra and composition of resin had no effect on wetting, except for SDR and TECBF due to the size of filler particles and prepolymers, respectively.Tétel Korlátozottan hozzáférhető Interventions to speed up orthodontic treatmentAbdel Nour, Diala; Hevesi, Judit; Fogorvostudományi Kar::Fogszabályozási nem önálló Tanszék; DE--Fogorvostudományi Kar; Bokonyi Csengeri, Aniko; Olah, Barbara; Fogorvostudományi Kar::Fogszabályozási nem önálló TanszékThis thesis explores practical and evidence-based ways to safely shorten orthodontic treatment time. It explains how tooth movement works at the biological level, especially the role of bone remodeling and the regional acceleratory phenomenon (RAP). Both surgical techniques, such as corticotomy and piezocision, and non-surgical methods, including laser therapy, vibration, electromagnetic fields, and certain medications, are carefully reviewed and compared. The study evaluates their effectiveness, safety, and possible side effects like root resorption or periodontal changes. It also discusses minimally invasive and conservative approaches that aim to improve patient comfort and treatment efficiency. Overall, this work provides a clear and balanced overview of how orthodontic treatment can be accelerated without compromising long-term stability or oral health.Tétel Korlátozottan hozzáférhető Rotary Glide Paths in EndodonticsPétursson, Elías Arnar; Nagy, László; Fogorvostudományi Kar::Konzerváló Fogászati nem önálló Tanszék; DE--Fogorvostudományi Kar; Suta, Péter; Balogh, Bettina; Fogorvostudományi Kar::Konzerváló Fogászati nem önálló TanszékThe thesis reviews the role of rotary and reciprocating glide path instruments in modern endodontic treatment, with emphasis on their mechanical behaviour, clinical performance and influence on shaping outcomes.Tétel Korlátozottan hozzáférhető Removal Possibilites of SealersQuraiseh, Amru; László, Nagy; Fogorvostudományi Kar::Konzerváló Fogászati nem önálló Tanszék; DE--Fogorvostudományi KarThis paper examines the potential for the removal of a variety of endodontic sealers during nonsurgical retreatment, a crucial step in the process of ensuring successful canal disinfection and re-obturation. The research analyzes the ease of removal of contemporary sealers, such as zinc oxide-eugenol, epoxy resin, bioceramic, and silicone-based materials, by categorizing them based on their unique chemical compositions and bonding mechanisms. In contrast to conventional materials such as zinc oxide-eugenol, which are relatively simple to retrieve and rely on mechanical retention, contemporary bioceramic and epoxy resin sealers establish robust chemical or mechanical bonds and deep tubule penetration, which significantly complicate its removal. Complete debridement is further impeded by anatomical complexities, including curved canals, isthmuses, and fins, which frequently result in residual coatings that can harbor persistent bacteria. The research assesses a variety of mechanical, chemical, and adjunctive techniques, observing that, although no single method guarantees complete elimination, the efficacy of sealer-specific solvents, such as 10% formic acid for bioceramics or Endosolv R for resins, can be improved. The thesis ultimately finds that the most predictable outcome for attaining maximal sealer reduction and long-term clinical success is a combined chemo-mechanical approach that integrates rotary instrumentation with ultrasonic or sonic irrigation activation.Tétel Korlátozottan hozzáférhető Resin matrix ceramics in dentistryElbakry, Yousra; Suta , Gábor András; Fogorvostudományi Kar::Bioanyagtani és Fogpótlástani Nem Önálló Tanszék; DE--Fogorvostudományi KarResin matrix ceramics (RMCs) represent an innovative category of CAD/CAM restorative materials that combine the high durability of ceramics with the elasticity and repairability of polymer resins. This thesis analyzes the structure, classification, and clinical performance of RMCs, highlighting their unique ability to mimic the biomechanical properties of natural dentin and enamel. Through a comprehensive literature review, the research evaluates the various subgroups of RMCs, including resin nanoceramics and polymer-infiltrated ceramic networks (PICNs), and their suitability for minimally invasive restorations such as inlays, veneers, and implant-supported crowns. Clinical data indicates high survival rates exceeding 95% over three years, with a notable advantage in stress distribution that reduces the risk of catastrophic fractures compared to traditional brittle ceramics. Despite these benefits, limitations such as lower wear resistance relative to lithium disilicate and a need for further long-term clinical research on fatigue performance are identified. Ultimately, the integration of RMCs into digital workflows facilitates efficient, single-session restorative procedures that bridge the gap between artificial reconstruction and natural dentition.Tétel Korlátozottan hozzáférhető Assesment of Glycemic Control in Periodontal DiseaseMirzazadeh, Kian; Tar, Ildiko; Fogorvostudományi Kar; DE--Fogorvostudományi Kar; Gebri, Eniko Zsuzsa; Molnar, LillaDiabetes mellitus and periodontitis share a strong bidirectional relationship, in which hyperglycemia increases periodontal inflammation and tissue destruction, while periodontal inflammation worsens insulin resistance and glycaemic control. Chronic hyperglycemia promotes oxidative stress, advanced glycation end-product (AGE) accumulation, immune dysregulation, and a shift toward pro-inflammatory pathways (M1 macrophages, Th17 cells), all of which accelerate periodontal breakdown. Conversely, periodontal infection elevates systemic inflammatory mediators such as IL-1β, IL-6, and TNF-α, contributing to poorer metabolic control in diabetic patients. Non-surgical periodontal therapy (scaling and root planing) can modestly improve HbA1c levels and reduce systemic inflammation, highlighting the clinical importance of integrated care.Tétel Korlátozottan hozzáférhető Application of pulp derived stem cells in dentistryAl-Rayiss, Momin; Edit, Hrubi; Fogorvostudományi Kar; DE--Fogorvostudományi Kar; Mohacsi, Rita; Biacsko, Csilla; Fogorvostudományi KarThis thesis provides a comprehensive review of dental pulp stem cells (DPSCs) and their potential applications in regenerative dentistry. DPSCs are mesenchymal stem cells derived from the neural crest and isolated from dental pulp tissue, most commonly from third molars or deciduous teeth. Due to their high proliferative capacity, multilineage differentiation potential, and immunomodulatory properties, DPSCs have emerged as promising candidates for regenerative therapies in dentistry and craniofacial medicine. The thesis first discusses the biological characteristics of DPSCs, including their isolation methods, surface marker expression, and differentiation capabilities. Particular emphasis is placed on their osteogenic, chondrogenic, and neurogenic potential, as well as the signaling pathways involved in lineage commitment, such as Wnt/β-catenin, BMP, PI3K/Akt, MAPK, and TGF-β/Smad pathways. Their immunomodulatory functions are also examined, highlighting their ability to regulate inflammatory responses and promote tissue healing through paracrine signaling and interaction with immune cells. The clinical relevance of DPSCs is explored in several key areas of regenerative dentistry. These include pulp–dentin complex regeneration, periodontal tissue regeneration, bone tissue engineering, and whole-tooth regeneration. Current preclinical and early clinical studies demonstrate promising outcomes in tissue formation, vascularization, and functional restoration. However, challenges remain, including donor variability, lack of standardized protocols, scaffold optimization, regulatory considerations, and limited long-term clinical data. The thesis concludes that DPSCs represent a significant advancement in regenerative dentistry, offering the potential to shift clinical practice from traditional replacement therapies toward true biological regeneration. Continued research, technological innovation, and well-designed clinical trials are essential to ensure safe and effective translation into routine dental practice.Tétel Korlátozottan hozzáférhető Minimal invasiveness in nonsurgical periodontal therapyAzin, Jafarzadeh; Varga, István; Fogorvostudományi Kar; DE--Fogorvostudományi Kar; Hernádi, Katinka; Oláh, Martin; Fogorvostudományi KarPeriodontal disease is a chronic inflammatory condition affecting the supporting structures of the teeth and is a leading cause of tooth loss worldwide. Conventional treatment may involve surgical procedures, which can result in increased morbidity, discomfort, gingival recession, and higher costs. This thesis focuses on minimally invasive nonsurgical periodontal therapy (MINST), a patient-centered approach that prioritizes tissue preservation, comfort, and biological healing while maintaining clinical effectiveness. It explains the biological basis of periodontal destruction, emphasizing dysbiotic biofilm and host-mediated inflammation, and outlines key techniques such as precise root debridement, adjunctive therapies, and advanced technologies. Overall, MINST aims to achieve effective clinical outcomes with reduced trauma and cost; however, further long-term studies and standardized protocols are needed to confirm its effectiveness and optimize its application.Tétel Korlátozottan hozzáférhető Risk factors for oral candidiasisAskarnia Amiri, Kimia; Ildiko, Tar; Fogorvostudományi Kar; DE--Fogorvostudományi Kar; Gebri, Eniko zsuzsa; Molnar, LillaOral candidiasis is a common opportunistic fungal infection, mainly caused by Candida albicans, that develops when the balance between the oral microbiome and host immunity is disturbed. This thesis is a structured literature review analyzing its epidemiology, etiopathogenesis, and especially the major risk factors associated with the disease. The prevalence is significantly higher in high-risk groups such as infants, denture wearers, elderly individuals, diabetic patients, and immunocompromised patients. The main conclusion is that oral candidiasis results from the interaction of microbial virulence and biofilm formation with local, systemic, behavioral, and iatrogenic risk factors. The study also addresses antifungal resistance, clinical classification, management strategies, and existing gaps in current knowledge.Tétel Korlátozottan hozzáférhető Orthodontics and Speech TherapyRozario, Christopher Richard; Török , Judit; Fogorvostudományi Kar::Fogszabályozási nem önálló Tanszék; DE--Fogorvostudományi Kar; Hamid , Leila; Sánta, Emese; Fogorvostudományi Kar::Fogszabályozási nem önálló TanszékThis thesis reviews how malocclusions and orthodontic treatments influence speech production by altering tongue position, airflow, and oral resonance. Conditions such as anterior open bite, increased overjet, and skeletal discrepancies can cause articulation distortions, particularly affecting sibilant sounds. Orthodontic appliances may temporarily affect speech, while early treatment and interdisciplinary care can help prevent persistent articulation patterns. The thesis emphasizes collaboration between orthodontists and speech-language pathologists, with orofacial myofunctional therapy supporting improved function, speech intelligibility, and long-term treatment outcomes.Tétel Korlátozottan hozzáférhető Role of steroids in dentoalveolar surgerySbeiti, Ali; taskó, Máté; Fogorvostudományi Kar; DE--Fogorvostudományi Kar; Kalas, nándor; hegedüs, nándor; Fogorvostudományi Kar::Dentoalveoláris Sebészeti nem önálló TanszékThis thesis reviews the role of steroids in dentoalveolar surgery, recent information regarding the efficacy of corticosteroids in alleviating postoperative pain, edema, and trismus. Furthermore, it seeks to evaluate the safety profile of corticosteroids administration in the clinical settings and to determine optimal practice protocols including drug selecton, dosage, administration route and timing.Tétel Korlátozottan hozzáférhető Intraoral scanners, extraoral scanners and 3D printers in orthodontic treatmentsGunnsteinsson, Jon Agust; Géza, Vitályos; Fogorvostudományi Kar::Fogszabályozási nem önálló Tanszék; DE--Fogorvostudományi Kar; Judit, Török; Barbara, Oláh; Fogorvostudományi Kar::Fogszabályozási nem önálló TanszékThis thesis focuses on scanners and printers in orthodontic treatments. It compares advantages and disadvantages of modern versus traditional methods, their accuracy, cost and convenience.Tétel Korlátozottan hozzáférhető Bone Ring TechniqueWang, Qiao; Hegedüs, Nándor; Fogorvostudományi Kar; DE--OEC--Fogorvostudományi Kar; D. Tóth, Etelka; Kovács, Máté; Fogorvostudományi KarThis thesis reviews the Bone Ring Technique as a one-stage method for simultaneous alveolar ridge augmentation and implant placement in deficient ridges. It summarizes the biological rationale, surgical protocol, and clinical indications of the technique. The work compares autogenous, allogenic, and xenogenic bone rings and discusses their advantages and limitations. Clinical evidence regarding bone gain, implant survival, and complications is analyzed. The thesis concludes that BRT is a time-efficient and predictable alternative to conventional staged augmentation when applied in properly selected cases.Tétel Korlátozottan hozzáférhető Periodontal Management In Children And AdolescentsAbdalla Mansour Ahmed, Mohamed; János, Angyal; Fogorvostudományi Kar::Parodontológiai nem önálló Tanszék; DE--Fogorvostudományi Kar; Nemes, Judit Ágnes; Hernádi, Katinka; Fogorvostudományi Kar::Gyermekfogászati és Prevenciós nem önálló Tanszék; Fogorvostudományi Kar::Parodontológiai nem önálló TanszékThis thesis reviews periodontal management in children and adolescents. Periodontal diseases in children range from common gingivitis to destructive periodontitis, which is increasingly recognized as a significant global public health concern across all age groups. While gingivitis affects about one-third of adolescents, periodontitis rates vary widely due to regional differences in socioeconomic factors and oral hygiene practices. Because early childhood conditions can progress and lead to systemic health issues, timely detection and preventive strategies are considered essential. This thesis aims to critically evaluate the epidemiology and behavioral risk factors of these conditions in populations under 18 years of age. By assessing current screening and prevention methods, the review seeks to provide a comprehensive understanding of periodontal health management in young patients.Tétel Korlátozottan hozzáférhető Usage of resorbable and non-resorbable sutures in oral surgeryFrancuz, Andrea; Lukács, Géza Levente; Fogorvostudományi Kar; DE--Fogorvostudományi Kar; Kovács , Máté; Taskó, Máté; Fogorvostudományi KarSutures are a fundamental component of surgical practice, serving as biomaterials that approximate tissues, stabilize wound margins, control bleeding, and promote healing. Their selection along with appropriate needle type, and suturing technique directly influences tissue response, healing quality, and patient comfort, particularly in oral surgery where unique biological and mechanical challenges exist. This thesis provides a comprehensive overview of suture materials, covering their historical development, modern innovations, and clinical application. Sutures are classified by origin (natural and synthetic), biological behaviour (absorbable and non-resorbable), and structure (monofilament, multifilament, and pseudo monofilament), with each type exhibiting distinct structural, mechanical, biological, and physical properties that influence response and healing.Tétel Korlátozottan hozzáférhető Physiotherapy in the management of TMDGestsdóttir, Kristrún; Márton, Suta; DE--Fogorvostudományi KarThis thesis examines the role of physiotherapy in the management of temporomandibular disorders (TMDs), which are multifactorial conditions affecting the temporomandibular joint, masticatory muscles, and associated structures. It outlines the anatomy, aetiology, classification, diagnosis, and current treatment approaches for TMDs, emphasizing their biopsychosocial nature and significant impact on patients’ quality of life. The review highlights conservative, non-invasive management as the first-line approach, with physiotherapy—particularly manual therapy and therapeutic exercises—playing a central role. Evidence from recent systematic reviews and clinical studies demonstrates that physiotherapy can significantly reduce pain, improve maximal mouth opening, enhance function, and support long-term rehabilitation. The thesis concludes that an integrated approach combining manual therapy, exercise, patient education, and behavioural interventions provides the most effective strategy, while further high-quality research is needed to determine optimal treatment protocols. This thesis examines the role of physiotherapy in the management of temporomandibular disorders (TMDs), which are multifactorial conditions affecting the temporomandibular joint, masticatory muscles, and associated structures. It outlines the anatomy, aetiology, classification, diagnosis, and current treatment approaches for TMDs, emphasizing their biopsychosocial nature and significant impact on patients’ quality of life. The review highlights conservative, non-invasive management as the first-line approach, with physiotherapy—particularly manual therapy and therapeutic exercises—playing a central role. Evidence from recent systematic reviews and clinical studies demonstrates that physiotherapy can significantly reduce pain, improve maximal mouth opening, enhance function, and support long-term rehabilitation. The thesis concludes that an integrated approach combining manual therapy, exercise, patient education, and behavioural interventions provides the most effective strategy, while further high-quality research is needed to determine optimal treatment protocols.Tétel Korlátozottan hozzáférhető Prosthetic Rehabilitation Of Maxillofacial Patients Suffering From Intraoral Bone DefectsGwandu, Fatima Bello Ibrahim; Petercsak , Anita; Fogorvostudományi Kar; DE--Fogorvostudományi Kar; Bukovinszky , Katalin; Hegymegi, Gergely; Fogorvostudományi KarIntraoral bone defects in maxillofacial patients can result from conditions such as tumor resection, cysts, trauma, congenital anomalies, and osteonecrosis, significantly affecting mastication, speech, appearance, and quality of life. These defects require complex prosthetic rehabilitation to restore oral function and esthetics. Modern prosthetic solutions include removable, fixed, or implant-supported devices tailored to individual patient needs. Obturators, palatal lift prostheses, and speech aids help restore separation between oral and nasal cavities, improving swallowing, speech, and chewing. In cases of severe bone loss, zygomatic and pterygoid implants provide reliable alternatives when conventional implants are not feasible. Additionally, CAD/CAM technology has enhanced the precision, fit, and efficiency of prosthetic rehabilitation, improving functional and aesthetic outcomes while reducing fabrication errors.