This thesis presents the development of an orally disintegrating tablet (ODT) formulation containing ketoprofen, intended for pediatric use. The aim was to create a child-friendly dosage form with rapid disintegration, adequate mechanical strength, and acceptable taste. A range of excipients, including co-processed blends of lactose, microcrystalline cellulose (MCC), and low-substituted hydroxypropyl cellulose (L-HPC), were evaluated to optimize the formulation. Comprehensive assessments were conducted on hardness, disintegration time, and dissolution behavior to identify the most effective composition. The findings demonstrate the potential of this formulation approach to enhance pediatric compliance and therapeutic effectiveness. The study contributes to the advancement of innovative drug delivery systems tailored for pediatric patients.