Heart failure is characterized by the presence of signs and symptoms due to congestion or inadequate cardiac output all leading to activation of various neurohormonal system such as RAAS and SNS. The treatment of HF solely depends on underlying cause. Drugs such as ACEi , ARB, beta blockers are all been used for many years. Natriuretic peptides activation and release during HF are proved to be beneficial due to the fact that these are diuretics, vasodialators, supress the RAAS and SNS and etc. Certainly prolonging the NPs half life would alleviate much of the symptoms and decrease the morbidity as well as mortality of HF hence inhibiting the neprilysin as enzyme degrading the NPs is a big step in cardiology pharmacotherapy.