Synthesis of ruthenium half-sandwich type complexes with C-glycosyl-formaldehyde imine ligands

Abstract

The thesis focuses on the synthesis and study of ruthenium half-sandwich complexes with sugar-based ligands, aiming to explore their potential as anticancer agents. Glycomimetics, which are synthetic sugar analogs, play a crucial role in mimicking biological processes and overcoming the limitations of natural glycans in drug development. Using advanced synthetic methods, several ruthenium complexes were successfully prepared and characterized with techniques like NMR and mass spectrometry. These complexes showed promise due to their structural stability and potential biological activity. The study contributes valuable insights into the design of multitargeted metallodrugs. The research lays the groundwork for developing safer and more effective therapies for cancer and possibly antimicrobial applications.