Epidermal barrier changes in Acne Vulgaris

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dc.contributor.advisorDull, Katalin
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Bőrgyógyászati Klinikahu_HU
dc.contributor.authorUchiyama, Eri
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentHegyi, Zoltán
dc.contributor.opponentCsonka, Tamas
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Anatómiai, Szövet- és Fejlődéstani Intézethu_HU
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Pathológiai Intézethu_HU
dc.date.accessioned2022-08-15T09:07:48Z
dc.date.available2022-08-15T09:07:48Z
dc.date.created2022-02-14
dc.description.abstractAcne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit and commonly occurs in adolescents and young adulthood. We investigated and compared the expressions of epidermal barrier proteins of healthy, sebaceous gland-rich (SGR) skin and AV samples by immunohistochemistry (IHC). Our results showed significant changes in expressions of proteins in samples with AV compared to SGR skin samples, which have roles in corneocyte envelope formation, desmosome organization, corneocyte desquamation, tight junction formation, barrier alarmins antimicrobial proteins. We proved the damage in skin barrier functions in AV, which also highlights the importance of appliance of the barrier-improving agents simultaneously with acne therapy to improve the effectiveness of the therapy.hu_HU
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent38hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/336455
dc.language.isoenhu_HU
dc.subjectAcne Vulgaris, Epidermal barrierhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudomány::Bőrgyógyászathu_HU
dc.titleEpidermal barrier changes in Acne Vulgarishu_HU
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