Abnormal Vimentin and Histone H3p.K27me3 immunohistochemical expression patterns as potential surrogate markers for 1p/19q-codeletion in adult-type diffuse gliomas

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dc.contributor.advisorBedekovics, Judit
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Pathológiai Intézet
dc.contributor.authorNinan, Rachael Suzanne
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.date.accessioned2025-07-02T08:06:30Z
dc.date.available2025-07-02T08:06:30Z
dc.date.created2025-06-16
dc.description.abstractThe retrospective study outlined in this thesis focuses on two adult-type diffuse gliomas - oligodendrogliomas and astrocytomas. Since both neoplasms possess several overlapping histological features, the identification of unique aberrations using molecular tests is essential for accurate diagnosis. However, these tests are generally less accessible and more expensive with longer turn-around times compared to immunohistochemical tests. The investigation aims to determine if variations in vimentin and histone H3p.K27me3 immunohistochemical expression could substitute for the 1p/19q-codeletion to effectively differentiate between the two gliomas. The correlation between these immunohistochemical stains and various histological features is also evaluated. Additionally, a review of the current literature pertaining to both central nervous system (CNS) tumors and the immunohistochemical markers is included.
dc.description.courseáltalános orvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent32
dc.identifier.urihttps://hdl.handle.net/2437/395332
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectoligodendroglioma
dc.subjectastrocytoma
dc.subject1p/19q-codeletion
dc.subjectvimentin
dc.subjecthistone H3
dc.subject.dspaceMedicine::Molecular Pathology
dc.titleAbnormal Vimentin and Histone H3p.K27me3 immunohistochemical expression patterns as potential surrogate markers for 1p/19q-codeletion in adult-type diffuse gliomas
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