Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope

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dc.contributor.authorAl-Omari, Mothana K.
dc.contributor.authorElaarag, Mai
dc.contributor.authorAl-Zoubi, Raed M.
dc.contributor.authorAl-Qudimat, Ahmad R.
dc.contributor.authorZarour, Ayman A.
dc.contributor.authorAl-Hurani, Enas A.
dc.contributor.authorFares, Zainab E.
dc.contributor.authorAlkharraz, Leena M.
dc.contributor.authorShkoor, Mohanad
dc.contributor.authorBani-Yaseen, Abdulilah D.
dc.contributor.authorAboumarzouk, Omar M.
dc.contributor.authorYassin, Aksam
dc.contributor.authorAl-Ansari, Abdulla A.
dc.contributor.authorZarour, Ayman A. (2023-) (xxx)
dc.contributor.submitterdepDebreceni Egyetem - Általános Orvostudományi Kar
dc.date.accessioned2023-07-11T10:04:07Z
dc.date.available2023-07-11T10:04:07Z
dc.date.oa2023-08-01
dc.date.updated2023-07-11T10:04:07Z
dc.description.abstractBoronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer therapy capture agents, and can mimic certain types of antibodies to fight infections. They have been designed and developed into drugs, and this approach has emerged in the last 20 years. Five boronic acid drugs have been approved by the FDA and Health Canada, two of which are used to treat cancer, specifically multiple myeloma. The purpose of this review is to investigate boronic acid/ester derivatives as potential pharmaceutical agents as well as the mechanism of action. It will concentrate on six types of cancer: multiple myeloma, prostate cancer, breast cancer, lung cancer, cervical cancer, and colon cancer. Some newly developed boron-containing compounds have already demonstrated highly promising activities, but further investigation is required before final conclusions can be drawn.
dc.description.correctorkzs
dc.identifier.citationJournal Of Enzyme Inhibition And Medicinal Chemistry. -38 : 1 (2023), p. 1-16. -J. Enzym. Inhib. Med. Chem. -1475-6366
dc.identifier.doi10.1080/14756366.2023.2220084
dc.identifier.issn1475-6366
dc.identifier.opachttps://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM113281
dc.identifier.urihttps://hdl.handle.net/2437/357414
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.1080/14756366.2023.2220084
dc.languageeng
dc.rights.accessopen access article
dc.rights.ownerszerző
dc.subject.otheridegen nyelvű folyóiratközlemény külföldi lapban
dc.titleOrganoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope
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