Enhanced Citric Acid Production in Aspergillus niger Through D-Glucose Tolerance.

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dc.contributor.advisorBíró , Vivien
dc.contributor.authorShalaby, Mennatallah
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Biotechnológiai Intézet
dc.date.accessioned2024-12-18T07:58:11Z
dc.date.available2024-12-18T07:58:11Z
dc.date.created2024-11-21
dc.description.abstractThis thesis focuses on optimizing citric acid production using Aspergillus niger, a fungus widely employed in industrial fermentation for its high efficiency and adaptability. Citric acid is a key compound in food, pharmaceutical, and cosmetic industries, primarily produced through microbial fermentation. The study investigates the impact of varying glucose concentrations on citric acid yield and fungal morphology. Experiments in manganese-free media showed that moderate glucose levels (180–260 g/L) supported optimal fungal growth with dense pellet formation and efficient citric acid production. Higher glucose levels (300 g/L and above) caused osmotic stress, leading to fragmented pellets and slower production rates. By analyzing glucose consumption and citric acid synthesis through high-performance liquid chromatography (HPLC), the research highlights the importance of controlling fermentation parameters like glucose levels, pH, temperature, and aeration. These insights contribute to developing sustainable, scalable, and cost-effective industrial processes, solidifying A. niger as a cornerstone organism in biotechnology.
dc.description.courseBiochemical Engineering
dc.description.degreeBSc/BA
dc.format.extent32
dc.identifier.urihttps://hdl.handle.net/2437/383839
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectAspergillus niger
dc.subjectCitric Acid
dc.subjectFermentation Parameters
dc.subjectD-Glucose Tolerance
dc.subjectIndustrial biotechnology
dc.subjectFungal morphology
dc.subjectSustainable production
dc.subject.dspaceBiology
dc.subject.dspaceChemistry::Biochemistry
dc.subject.dspaceEngineering Sciences::Engineering
dc.titleEnhanced Citric Acid Production in Aspergillus niger Through D-Glucose Tolerance.
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