Nausea and vomiting during pregnancy are one of the most common pregnancy-related complaints, shown to badly affect women`s daily life in various aspects. Many women consider taking medication for their symptoms, but this decision still hard because there is little evidence about the safety or effectiveness of most of the drugs. The etiology and pathophysiology of emesis and hyperemesis gravidarum describe in the first chapter. The second chapter deal with the various form of management nausea and vomiting during pregnancy, mechanism of action, its benefits, and the risks. The third chapter will discuss the increased use of marijuana among pregnant women in recent years suffered from nausea and vomiting and the complicated effects of cannabinoid on the gastrointestinal tract.