Non-Vitamin K Antagonist Oral Anticoagulants (NOACs) have revolutionized the field of anticoagulation therapy, offering a significant advancement over conventional anticoagulants like warfarin. NOACs have demonstrated efficacy in various clinical indications, including stroke prevention in NVAF, treatment and prevention of DVT and PE, and prevention of venous thromboembolism following orthopaedic surgeries.