BACH1 and Its Role in Modulating the Inflammatory Response of Macrophages

A tétel rövid nézete
dc.contributor.advisorNagy, László
dc.contributor.advisorBene, Krisztián
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Biokémiai és Molekuláris Biológiai Intézet
dc.contributor.authorHussein, Mohamed Osama Kamalaldin
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.date.accessioned2024-11-14T11:22:40Z
dc.date.available2024-11-14T11:22:40Z
dc.date.created2024-05-21
dc.description.abstractThe study investigated the role of BACH1 in regulating inflammatory responses in macrophages (MFs). BACH1 was found to bind genomic regions with key MF transcription factors, suggesting it influences genes related to pattern-recognition receptor (PRR) signaling pathways. Using bone marrow-derived macrophages (BMDM) from Bach1 knock-out (KO) and control mice, We confirmed Bach1 deletion via Western blot and assessed transcriptional changes. We observed increased expression of genes related to inflammation, such as Il1b, Il6, and Il10, in a BACH1-dependent manner, particularly following LPS treatment. The KO cells also showed heightened levels of HMOX1 protein and altered cytokine production, including IL-6, measured by ELISA. The absence of BACH1 affected inflammatory responses in both alveolar and peritoneal macrophages, supporting the idea that BACH1 modulates inflammation across diverse MF types and activation states.
dc.description.courseáltalános orvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent35 pages
dc.identifier.urihttps://hdl.handle.net/2437/382077
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectBACH1
dc.subjectmacrophages
dc.subjectimmune response
dc.subjectinflammation
dc.subjectcytokines
dc.subjectchemokines
dc.subjectextended synergy
dc.subject.dspaceBiology::Biochemistry
dc.titleBACH1 and Its Role in Modulating the Inflammatory Response of Macrophages
Fájlok
Eredeti köteg (ORIGINAL bundle)
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
thesis doc-final-v6.pdf
Méret:
2.31 MB
Formátum:
Adobe Portable Document Format
Leírás:
Megjelenítés
Engedélyek köteg
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
license.txt
Méret:
1.94 KB
Formátum:
Item-specific license agreed upon to submission
Leírás:
Letöltés
Gyűjtemények
Theses (Faculty of Medicine)