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Pharmacological Management of Ventricular Extrasystoles

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This document is the M.D. thesis by Phan Le Phuc Tuong from the University of Debrecen, titled "Pharmacological Management of Ventricular Extrasystoles." It includes the following sections: Declaration: A signed declaration by the author affirming the originality of the work and understanding of plagiarism. Thesis Content: The main body of the thesis covers the definition, classification, mechanisms, epidemiology, and clinical implications of Ventricular Extrasystoles (VEs), also known as Premature Ventricular Contractions (PVCs). It emphasizes that while VEs can be benign, they can also signal severe risks, especially in patients with existing heart conditions. Management and Classification: It details the pharmacological management of VEs, focusing on anti-arrhythmic drugs categorized under the Vaughan-Williams (VW) classification. The thesis discusses Class I (sodium channel blockers), Class II (beta-blockers), Class III (potassium channel blockers), and Class IV (calcium channel blockers), as well as other drugs like ranolazine and ivabradine. It highlights that a tailored approach is necessary for managing VEs, considering patient-specific factors to improve outcomes. Appendix/References: The document concludes with a list of references supporting the research.(2,01 MB)

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Absztrakt

This thesis provides a comprehensive and well-structured examination of the pharmacological management of ventricular extrasystoles (VEs). It effectively outlines the pathophysiology, classification, and clinical significance of VEs, establishing a strong foundation for the subsequent discussion on treatment strategies. The core of the work is a detailed analysis of antiarrhythmic drugs, systematically categorized by the Vaughan-Williams classification, which is thorough and informative. The thesis successfully integrates clinical insights and evidence-based findings to emphasize the need for a tailored approach to patient care, making it a well-rounded piece of scholarly work. The conclusion thoughtfully summarizes the key takeaways, reinforcing the importance of a holistic management strategy for VEs.

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Kulcsszavak

Ventricular Extrasystoles , Antiarrhythmic drug therapy , Pharmacological management

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https://hdl.handle.net/2437/395278

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Theses (Faculty of Medicine)

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Hozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.