Analysis of mRNA Expression of Genes Commonly Regulated by RAR and VDR Agonists in Differentiated THP1 Cells

dc.contributor.advisorSzéles, Lajos
dc.contributor.advisorMianesaz, Hamidreza
dc.contributor.advisorSzirák, Krisztina
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Humángenetikai Tanszék
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Humángenetikai Tanszék
dc.contributor.authorAlHaman, Farah Hisham Ahmad
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.date.accessioned2024-06-04T10:04:20Z
dc.date.available2024-06-04T10:04:20Z
dc.date.created2024
dc.description.abstractRetinoic acid receptor (RAR) and vitamin D receptor (VDR) are nuclear receptors that form heterodimers with RXR and regulate the expression of multiple genes. many genes are regulated by both RAR and VDR agonists (e.g. AM850 and 1α,25-dihydroxyvitamin D3, respectively) in multiple cell types. This study examines genes regulated by both AM580 (RARα specific agonist) and 1α,25-dihydroxyvitamin D3 (VDR agonist) in differentiated THP-1 cells focusing on mRNA induction kinetics and additive effects on gene activation.
dc.description.coursemolekuláris biológia
dc.description.courselangangol
dc.description.coursespecBiokémia-genomika
dc.description.degreeMSc/MA
dc.format.extent24
dc.identifier.urihttps://hdl.handle.net/2437/370889
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectTranscriptomics
dc.subjectVDR
dc.subjectRAR
dc.subjectmRNA Expression
dc.subjectRT-qPCR
dc.subjectTime course
dc.subjectPrimary gene induction
dc.subject.dspaceMedicine
dc.subject.dspaceBiology
dc.titleAnalysis of mRNA Expression of Genes Commonly Regulated by RAR and VDR Agonists in Differentiated THP1 Cells
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