Glaucoma refers to a group of eye conditions characterized by the gradual deterioration of retinal ganglion cells and damage to the optic nerve. This process results in the loss of peripheral vision and, in severe cases, can lead to blindness. It is the second most common cause of blindness and the most common cause of irreversible blindness worldwide. Glaucoma may or may not be accompanied increased intraocular pressure however, ocular hypertension is the major modifiable risk factors and most of the management strategies aim to decrease it. In the following thesis the treatment of glaucoma will be comprehensively discussed focusing on the pharmacological treatment of glaucoma. The current pharmacological treatment will be discussed as well as the new novel drugs and drugs currently in development. The drugs mechanism of action, clinical implications and side effects are explained in detail in this review.