Pharmacotherapy of Neurodegenerative Diseases

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a fatal idiopathic neurodegenerative disease that is characterized by degeneration of both upper and lower motor neurons. ALS currently only has 2 drugs approved as disease modyfying, whereas the rest of the therapy is palliative. Huntingtons Disease (HD) is a neurodegenerative disorder that impairs motor and cognitive functions. Advances in understanding the basic pathological mechanism(s) of HD has yet to translate into an effective disease-modifying therapy