This M.D. thesis aims to provide a general review and summary on the immuno-chemotherapy of HNSCC. First, an overview of the head and neck anatomy will be presented to provide a broad systemic outlook. It will then be followed by the epidemiology and risk factors. Pathogenesis in its molecular level will also be discussed. Finally, the important clinical aspects and the current immuno-chemotherapeutic strategy of HNSCC will be reviewed.