The main purpose of this paper is to study how Chinese companies can prevent problems of cross-cultural communication caused by cultural differences in international business. The specific research objectives are to solve the problems faced by Chinese companies in international business negotiations. The topic-related research tasks include the impact of cultural differences, aspects of international business negotiations affected by cultural differences, the difference in language, and the impact of cultural differences on marketing. The research direction around this topic is cultural differences related. Then in the study of cultural differences, this paper discusses the practical problems that Chinese enterprises encounter in international business negotiations. This paper combines theoretical and practical analysis in order provide some practical conclusions and recommendations.