Histone Deacetylase Inhibitors: Novel advances in Cancer Therapy

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDepartment of Pharmacology and Pharmacotherapyhu_HU
dc.contributor.authorQuach, Khong Tri
dc.contributor.departmentDE--Gyógyszerésztudományi Karhu_HU
dc.contributor.opponentDrimba, László
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentdeptKenézy Kórház Központi Aneszteziológiai és Intenzív Terápiás Osztályhu_HU
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.date.accessioned2019-01-31T11:25:33Z
dc.date.available2019-01-31T11:25:33Z
dc.date.created2018-06-15
dc.description.abstractNowadays, it became evident that the onset of cancer and its progression may not occur only due to genetic mutations but also because of changes in the patterns of epigenetic modifications. In contrast to genetic mutations, which are almost impossible to reverse, epigenetic changes are potentially reversible. This implies that they are susceptible to pharmacological interventions. Therefore, a lot of work in recent years has focussed on the development of small molecule enzyme inhibitors like DNA-methyltransferase inhibitors or inhibitors of histone-modifying enzymes. Today, several epigenetic drugs are already approved by the FDA for cancer treatment and around ten histone deacetylase (HDAC) inhibitors are in clinical development. The purposes of this thesis are • Understand about mechanisms of action of HDAC inhibitors • Drugs are already approved by the FDA for cancer treatment and histone deacetylase (HDAC) inhibitors are in clinical developmenthu_HU
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent38hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/263457
dc.language.isoenhu_HU
dc.subjecthistone deacetylase inhibitorshu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleHistone Deacetylase Inhibitors: Novel advances in Cancer Therapyhu_HU
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