Pharmacotherapy of migraine is a difficult part of medicine. Migraine is an episodic, unpradictable type of headaches that presents with disabling attacks. These attacks can be succesfully treated with acute medications. Those include triptans, ergotamins, dihydroergotamines, and NSAID. The objective of this thesis was the details of the strategy of migraine treatment. In addition, other things will be discussed: pathophysiology, and clinical signs of migraine, specific and non-specific therapy, treatment of status migreneous, surgical and alternative therapy. The most common used therapy of migraine is analgesic, ergotamines, triptans and NSAID. These drug’s chemical structures, physiological function, benefits and side effects also will be presented in this work.