Pharmacology of New and Emerging Targeted Drugs for Advanced Breast Cancer

dc.contributor.advisorMegyeri, Attila
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.contributor.authorBetiar, Hedieh
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.contributor.opponentSzentmikósi, József
dc.contributor.opponentHalasi, Barbara
dc.contributor.opponentdeptÁltalános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.contributor.opponentdeptÁltalános Orvostudományi Kar::Igazságügyi Orvostani Intézet
dc.date.accessioned2025-07-08T09:21:09Z
dc.date.available2025-07-08T09:21:09Z
dc.date.created2025-05-11
dc.description.abstractThe recent progresses in targeted therapy have been successful to present a more precise and effective therapeutic option for the management of breast cancer, specifically the advanced cases. Considering the heterogeneity of breast cancer, a thorough understanding of the molecular, genetic, and immunological behavior of tumor cells as well as tumor microenvironment is the most imperative feature to reaching anticipated therapeutic accomplishment with targeted or immune therapy. This thesis focuses on emerging targeted therapies such as anti-human epidermal growth factor 2 (HER2) therapy, endocrine therapy (ET), cyclin D kinase 4/6 (CDK4/6) inhibitors, phosphatidylinositol 3-kinase (PI3K) /protein kinase B (AKT) /mammalian target of rapamycin (mTOR) pathway inhibitors, Poly ADP-ribose polymerase (PARP) enzyme inhibitors, programmed cell death protein1 (PD-1)/ programmed cell death ligand 1 (PD-L1) inhibitors, and cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) inhibitors, and their challenges and proposed solutions.
dc.description.courseáltalános orvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent64
dc.identifier.urihttps://hdl.handle.net/2437/395565
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectAdvanced breast cancer
dc.subjectTargeted therapy
dc.subjectHER2-Targeted Therapies
dc.subjectCDK4/6 Inhibitors
dc.subjectPI3K/AKT/mTOR Pathway Inhibitors
dc.subjectPARP inhibitors
dc.subjectImmune Checkpoint Inhibitors (PD-1/PD-L1, CTLA-4)
dc.subject.dspaceMedicine::Pharmacology
dc.subject.dspaceMedicine
dc.titlePharmacology of New and Emerging Targeted Drugs for Advanced Breast Cancer
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