Characterization of chimeric antigen receptor (CAR) Modified T Cells specific for P97 and HMW-MAA human melanoma
dc.contributor.advisor | Szöőr, Árpád | |
dc.contributor.advisordept | BIOPHYSICS AND CELL BIOLOGY | hu_HU |
dc.contributor.author | Pham, Huynh Thuy An | |
dc.contributor.department | DE--Gyógyszerésztudományi Kar | hu_HU |
dc.date.accessioned | 2019-05-21T09:22:13Z | |
dc.date.available | 2019-05-21T09:22:13Z | |
dc.date.created | 2019 | |
dc.description.abstract | Anti-p97 and HMW-MAA CAR T cells recognized Melur target cells in vitro. P97 CAR induced faster activation and better cytokine production of T cells, even though the HMW-MAA antigen is expressed to a similar extent on the target tumor cells and the HMW-MAA CAR is known to bind to its target with similar affinity as the p97 does. We hypothesize that a difference in the surface mobility of various melanoma associated antigens might have an impact on CAR T cell activation. | hu_HU |
dc.description.corrector | gj | |
dc.description.course | gyógyszerész | hu_HU |
dc.description.courselang | angol | hu_HU |
dc.description.degree | MSc/MA | hu_HU |
dc.format.extent | 23 | hu_HU |
dc.identifier.uri | http://hdl.handle.net/2437/267959 | |
dc.language.iso | en | hu_HU |
dc.subject | Chimeric Antigen Receptor | hu_HU |
dc.subject | Melanoma | |
dc.subject | Immunecell Therapy | |
dc.subject.dspace | DEENK Témalista::Orvostudomány | hu_HU |
dc.title | Characterization of chimeric antigen receptor (CAR) Modified T Cells specific for P97 and HMW-MAA human melanoma | hu_HU |
dc.title.translated | P97 ÉS HMW-MAA SPECIFIKUS KIMÉRA ANTIGÉN RECEPTOROK KARAKTERIZÁLÁSA HUMÁN MELANOMÁBAN | hu_HU |