Characterization of chimeric antigen receptor (CAR) Modified T Cells specific for P97 and HMW-MAA human melanoma

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dc.contributor.advisorSzöőr, Árpád
dc.contributor.advisordeptBIOPHYSICS AND CELL BIOLOGYhu_HU
dc.contributor.authorPham, Huynh Thuy An
dc.contributor.departmentDE--Gyógyszerésztudományi Karhu_HU
dc.date.accessioned2019-05-21T09:22:13Z
dc.date.available2019-05-21T09:22:13Z
dc.date.created2019
dc.description.abstractAnti-p97 and HMW-MAA CAR T cells recognized Melur target cells in vitro. P97 CAR induced faster activation and better cytokine production of T cells, even though the HMW-MAA antigen is expressed to a similar extent on the target tumor cells and the HMW-MAA CAR is known to bind to its target with similar affinity as the p97 does. We hypothesize that a difference in the surface mobility of various melanoma associated antigens might have an impact on CAR T cell activation.hu_HU
dc.description.correctorgj
dc.description.coursegyógyszerészhu_HU
dc.description.courselangangolhu_HU
dc.description.degreeMSc/MAhu_HU
dc.format.extent23hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/267959
dc.language.isoenhu_HU
dc.subjectChimeric Antigen Receptorhu_HU
dc.subjectMelanoma
dc.subjectImmunecell Therapy
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleCharacterization of chimeric antigen receptor (CAR) Modified T Cells specific for P97 and HMW-MAA human melanomahu_HU
dc.title.translatedP97 ÉS HMW-MAA SPECIFIKUS KIMÉRA ANTIGÉN RECEPTOROK KARAKTERIZÁLÁSA HUMÁN MELANOMÁBANhu_HU
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