Cardio-Protection and Heart Repair:-New Targets and Drugs

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.contributor.authorSaeed, Youmna
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.contributor.opponentSzentmiklósi, József
dc.contributor.opponentHalasi, Barbara Dóra
dc.contributor.opponentdeptÁltalános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.contributor.opponentdeptÁltalános Orvostudományi Kar::Igazságügyi Orvostani Intézet
dc.date.accessioned2025-08-14T07:05:59Z
dc.date.available2025-08-14T07:05:59Z
dc.date.created2025-06-20
dc.description.abstractCoronary artery disease is the leading cause of morbidity and mortality worldwide, needing innovative strategies for cardiac protection and repair. This thesis explores the fundamental principles of cardio-protection, distinguishing between acute and chronic mechanisms, and explains in detail the process of ischaemia/reperfusion (I/R) injury process as a target of therapeutic interventions. The molecular process of I/R injury is discussed, which consists of key processes like oxidative stress, mitochondrial dysfunction and calcium overload. Classical and emerging cardio-protective strategies which include ischaemic preconditioning, post-conditioning and remote conditioning, as well as targeted pharmaceutical therapies which are critically examined, include molecular targets like hypoxia-inducible factor-1, microRNAs and sodium-glucose cotransporter (SGLT-2) inhibitors. In addition, the role of existing drugs and their role as cardioprotective agents, like metformin, colchicine and cyclosporine A. Moreover, the innovation of antibody-based therapies, cell-based angiogenesis for cardiac repair with the application of biomarkers specific for cardiac repair monitoring. This paper highlights the interplay between molecular biology, pharmacology and the clinical application of targeted therapy aimed at reducing myocardial injury and promoting cardiac regeneration.
dc.description.courseáltalános orvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent36
dc.identifier.urihttps://hdl.handle.net/2437/396817
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectAcute Coronary Syndrome
dc.subjectCoronary Artery Disease
dc.subjectCardio-protection
dc.subjectIschaemia/reperfusion (I/R) injury
dc.subjectTargeted pharmaceutical therapy
dc.subject.dspaceMedicine
dc.titleCardio-Protection and Heart Repair:-New Targets and Drugs
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