In our research work, we developed a CE-MS method for the determination of different phenolic compounds present in a honey sample. Initial experiments were carried out to determine the appropriate MS method, and the use of a negative ionization mode proved advantageous. Then, for BGE and sheath liquid, a suitable CZE-MS method was designed, with the simplest choice being to use 0.5 M NH4OH and IPA:water (1:1 v/v%). The CE is regarded excellent for the analysis of samples with high matrix content, is very tolerant to complicated sample matrices, and works well in small volumes, therefore its combination with MS allows for highly selective compound detection while avoiding interferences and memory effects. The SPE technique was utilized to test the CZE-MS method using different compounds detected in honey samples. We attempted to match the experimental measurement data, such as migration time, with the standard measurements using this method, but we were unable. On the other hand, it was possible to anticipate that the estimated masses would be discovered during the detection analysis. Calibration curves, on the other hand, were performed as part of the quantitative measurements and demonstrated appropriate linearity of at least 0.99. As a result, only three phenolic compounds were discovered following a thorough quantitative and qualitative investigation. All three were identified as naringenin, ferulic acid and caffeic acid. My research work contributed to the compiling of a research paper published by our research group.