Pharmacological Exploitation of ACE2 Mechanism

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorAbdilov, Nurlan
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentDrimba, László
dc.contributor.opponentMegyeri, Attila
dc.contributor.opponentdeptKenézy Kórház, Központi Aneszteziológiai és Intezív Terápiás Osztályhu_HU
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.date.accessioned2022-08-15T10:08:49Z
dc.date.available2022-08-15T10:08:49Z
dc.date.created2022
dc.description.abstractAngiotensin-converting enzyme 2 (ACE2) or human homologue of ACE was first described in 2000. Although ACE2 is related to angiotensin-converting enzyme (ACE), it is not inhibited by ACE inhibitors. The major function of ACE2 is to degrade angiotensin II, resulting in the production of angiotensin 1–7 (Ang 1–7), which counteracts the activities of Ang II. This has altered our entire perspective on the part of renin-angiotensin system in the regulation of blood pressure, cardiac and renal function. ACE2 has important role in variety of conditions where its expression is reduced, such as in hypertension, CKD and cardiovascular pathologies. In these disorders, current therapy methods involving ACE2 include utilizing ACE2 adenoviruses, recombinant ACE2, or chemicals that increase its expression, hence providing some organ protection.hu_HU
dc.description.correctorhbk
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent44hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/336460
dc.language.isoenhu_HU
dc.subjectCovid-19hu_HU
dc.subjectSARS-CoV-2hu_HU
dc.subjectACE2 receptorhu_HU
dc.subjectrenin-angiotensin systemhu_HU
dc.subjectANG IIhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudomány::Farmakológiahu_HU
dc.titlePharmacological Exploitation of ACE2 Mechanismhu_HU
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