Exploring the Management Status of Uveal Melanoma

dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorYu, Xiao
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentDrimba, László
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.opponentdeptKenézy Kórház Központi Aneszteziológiai és Intenzív Terápiás Osztályhu_HU
dc.date.accessioned2019-01-30T12:34:07Z
dc.date.available2019-01-30T12:34:07Z
dc.date.created2018-09-26
dc.description.abstractIntra-ocular malignancy such as Uveal Melanoma (UM) arises from melanocytes from the uveal tract. It is paramount to detect early so as to initiate therapeutic plan as much of the survival will depend of the primary tumor size. Currently, no adjuvant therapy has demonstrated survival benefit and new insights in molecular biology, have improved our comprehension of the pathogenesis essentially through GNAQ and GNA11 mutations and downstream signaling pathways MAPK, PI3K/Akt and Hippo, representing a multitude of therapeutic application. New research has also unfolded new range of biomarkers that could be exploited in this setting so as to improve metastasis detection. Many studies and clinical trials are ongoing.hu_HU
dc.description.correctorSZG
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent35hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/263432
dc.language.isoenhu_HU
dc.subjectIntra-ocular malignancyhu_HU
dc.subjectUveal Melanoma
dc.subjecttherapeutic plan
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleExploring the Management Status of Uveal Melanomahu_HU
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