Effect of allithiamine on the level of hyperglycaemia-induced advanced glycation end products

A tétel rövid nézete
dc.creatorBíró, Attila
dc.creatorRemenyik, Judit
dc.date2019-12-15
dc.date.accessioned2021-06-28T11:01:46Z
dc.date.available2021-06-28T11:01:46Z
dc.descriptionDiabetes mellitus is a rapidly growing public health burden in both developed and developing countries. Diabetes mellitus is accompanied by hyperglycaemia, which can cause tissue injury by several mechanisms. One of these is the formation of advanced glycation end-products (AGEs). In this study, the effect of allithaimine, a fat-soluble thiamine derivative, was investigated on hyperglycaemia-induced AGEs levels using human umbilical cord vein endothelial cells (HUVECs) as a hyperglycaemic model. HUVECs were isolated by enzymatic digestion, characterized by flow cytometer and treated 30 mM glucose plus allithaimine or thiamine or cell maintenance medium as control.  Allithiamine was synthesized and purified. The structure of the synthesized and isolated compound was verified by reverse phase HPLC and MALDI-TOF. AGEs were evaluated by ELISA. Collectively, our results indicate that allithiamine can reduce level of the hyperglycaemia-induced AGEs similar to thiamine.
dc.formatapplication/pdf
dc.identifierhttps://ojs.lib.unideb.hu/actaagrar/article/view/3677
dc.identifier10.34101/actaagrar/2/3677
dc.identifier.urihttp://hdl.handle.net/2437/317091
dc.languageeng
dc.publisherFaculty of Agricultural and Food Sciences and Enviromental Management of the Debrecen University, Debrecen.
dc.relationhttps://ojs.lib.unideb.hu/actaagrar/article/view/3677/3642
dc.sourceActa Agraria Debreceniensis; No. 2 (2019); 41-44
dc.source2416-1640
dc.source1587-1282
dc.subjectallithiamine
dc.subjecthyperglycaemia
dc.subjectadvanced glycation end-products
dc.subjectendothelial cells
dc.titleEffect of allithiamine on the level of hyperglycaemia-induced advanced glycation end products
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Article
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Acta Agraria Debreceniensis