Pharmacological and Clinical Review of AchEI against NMDA antagonist in treatment of Alzheimer Dementia

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorChoi, Hyun Duck
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentDrimba, László
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.opponentdeptKenézy Kórház Aneszteziológiai és Intenziv Therápiás Osztályhu_HU
dc.date.accessioned2017-08-02T10:25:24Z
dc.date.available2017-08-02T10:25:24Z
dc.date.created2017-01-13
dc.description.abstractTo date, there are only symptomatic treatments approved by the FDA and in wide clinical usage: Rivastigmine, Galantamine, Donepezil, and Memantine. However, their actual clinical efficacy has been questionable, due to wide variance in clinical response between the patients. In this review, the clinical efficacy and safety/tolerability between the three AchEIs (rivastigmine, galantamine, donepezil) and NMDA antagonist were compared.Additionally, the clinical efficacy of AchEI and memantine combination therapy has been reviewed.Safety and tolerability of the drugs were also compared by analyzing the incidence of adverse effects.Besides the standard treatment options, treatment of concomitant neuropsychiatric symptoms, and drugs under clinical trials have also been reviewed.hu_HU
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent37hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/242811
dc.language.isoenhu_HU
dc.subjectAlzheimerhu_HU
dc.subjectDementiahu_HU
dc.subjectEfficacyhu_HU
dc.subjectSafetyhu_HU
dc.subjectTolerabilityhu_HU
dc.subjectComparisonhu_HU
dc.subjectAchEIhu_HU
dc.subjectNMDA antagonisthu_HU
dc.subjectAcetylcholinesterase inhibitorhu_HU
dc.subjectPharmacologicalhu_HU
dc.subjectClinicalhu_HU
dc.subjecttreatmenthu_HU
dc.subjectReviewhu_HU
dc.subjectMemantinehu_HU
dc.subjectDonepezilhu_HU
dc.subjectRivastigminehu_HU
dc.subjectGalantaminehu_HU
dc.subject.dspaceDEENK Témalista::Orvostudomány::Farmakológiahu_HU
dc.titlePharmacological and Clinical Review of AchEI against NMDA antagonist in treatment of Alzheimer Dementiahu_HU
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